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. Author manuscript; available in PMC: 2024 Nov 12.
Published in final edited form as: J Med Chem. 2023 Jan 26;66(3):1928–1940. doi: 10.1021/acs.jmedchem.2c01731

Fig. 5. Metabolic profiles of high affinity allosteric CDK2 inhibitors.

Fig. 5.

A. Metabolic stability in human and mouse microsomes for EF-3-006 and EF-4-177 (data provided by Pharmaron). B. EF-4-177 shows a long ½ life in mice and distribution into the testis. C. EF-4-177 significantly reduces sperm count after 28-day exposure in mice. Individual sperm counts are displayed in the scatter plot and summary statistics are expressed as the mean (x 106) ± S.D.