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. Author manuscript; available in PMC: 2024 Nov 12.
Published in final edited form as: Math Biosci. 2023 May 16;362:109021. doi: 10.1016/j.mbs.2023.109021

Fig. 4.

Fig. 4.

Predicted and measured precursors of MIT (A), DIT (B) and T4 (C), and follicular cell/thyrocyte numbers (D) in the thyroid gland of X. laevis larvae. Model predictions were obtained under control conditions (solid line) and when TPO activity was arbitrarily inhibited by 95% (dashed line). Solid points (mean ± SD) represent control datasets [21] used for model calibration. The sum of squared residuals (SSR) ratio indicates the proportional contribution of each endpoint to the overall model cost under control conditions. A — amount; MIT — monoiodotyrosine; DIT — diiodotyrosine; T4 — thyroxine; TL — thyroid lumen; FCN — follicular cell number; TOT — total.