Table 2.

Normalized sensitivity coefficients summed across the four modeled time points (2, 4, 7, and 10 d). Positive values indicate that an increase in the selected model parameter results in an increase in the predicted state variable. Negative values indicate that an increase in the selected model parameter results in a decrease in the predicted state variable. Please see main text and Table 1 for definitions of abbreviations.

	State variable
Model parameter	$C_{\text{T}3,\text{TOT},\text{PL}}$	$C_{\text{T}4,\text{TOT},\text{PL}}$	$FC{N}_{\text{TOT}}$	$A_{\text{MIT},\text{TL}}$
Most sensitive parameters with influence on certain variable(s)
$K_{\text{D},\text{T}3}$	−3.95	–	–	–
$K_{\text{D},\text{T}4}$	–	−3.93	–	–
$V_{\text{MAX},\text{DIO}2}$	–	−3.48	–	–
$K_{\text{M},\text{DIO}2}$	–	3.36	–	–
$R_{BW}$	−2.15	−2.20	–	–
$C{L}_{\text{T}3,\text{CONJ}}$	–	0.98	–	–
$n$	–	–	−1.16	–
$R_{\text{FCN},\text{MAX}}$	–	–	0.95	–
$V_{\text{MAX},\text{TG},\text{SYN}}$	–	–	–	3.01
$K_{\text{M},\text{TG},\text{SYN}}$	–	–	–	−2.25
$V_{\text{MAX},\text{DIO}2}$	–	–	–	−0.68
Most sensitive parameters influencing all variables
$C{L}_{\text{TSH}}$	−2.66	−2.72	−1.27	−1.47
$V_{\text{MAX},\text{TG},\text{PROT}}$	1.40	1.42	−1.26	−2.54
$K_{\text{M},\text{TG},\text{PROT}}$	−1.34	−1.35	1.22	2.46
$K_{\text{H}}$	−1.28	1.31	−2.54	−0.97
$FCV$	1.36	1.38	−1.23	1.21
$R_{{\text{V}}_{\text{MAX},\text{TSH}}}$	1.70	1.74	0.82	0.84
$R_{{\text{R}}_{{\text{K}}_{\text{M}},\text{TSH}}}$	1.67	1.71	0.81	0.81
$V_{\text{MAX},\text{DIO}3}$	−0.90	1.75	0.82	0.94
$K_{\text{M},\text{DIO}3}$	0.86	−1.66	−0.78	−0.91