Table 2.
Hair Proteins Mediating Differences between Mothers and Children
| Entrez Gene Name | Gene Symbol: human | Expr Log Ratio | P-value | Location | Type(s) |
|---|---|---|---|---|---|
| Involucrin | IVL | −2.85 | 0.0576 | Cytoplasm | other |
| Serpin family B member 4 | SERPINB4 | −2.452 | 0.0009*** | Cytoplasm | other |
| POF1B actin binding protein | POF1B | −2.097 | 0.0151* | Plasma Membrane | other |
| Plectin | PLEC | −1.886 | 0.0004*** | Cytoplasm | other |
| Alpha-2-macroglobulin like 1 | A2ML1 | −1.858 | 0.0042** | Cytoplasm | other |
| H3 clustered histone 1 | HIST1H3A | −1.743 | 0.0038** | Nucleus | other |
| Ubiquinol-cytochrome c reductase complex III subunit VII | UQCRQ | −1.716 | 0.0007*** | Cytoplasm | enzyme |
| Adenosylhomocysteinase | AHCY | −1.472 | 0.0040** | Cytoplasm | enzyme |
| Heat shock protein family A (Hsp70) member 1A | HSPA1A | −1.35 | 0.0569 | Cytoplasm | enzyme |
| H2B clustered histone 9 | HIST1H2BH | −1.17 | 0.507 | Nucleus | other |
| Histidine ammonia-lyase | HAL | −1.087 | 0.0851 | Cytoplasm | enzyme |
| COPI coat complex subunit zeta 1 | COPZ1 | −0.931 | 0.158 | Cytoplasm | transporter |
| Eukaryotic translation initiation factor 3 subunit A | EIF3A | −0.8 | 0.0567 | Cytoplasm | other |
| Tubulin alpha 1c | TUBA1C | −0.526 | 0.262 | Cytoplasm | other |
| Casein beta | CSN2 | −0.269 | 0.491 | Extracellular Space | kinase |
| ATP citrate lyase | ACLY | −0.249 | 0.0954 | Cytoplasm | enzyme |
| Protein disulfide isomerase family A member 3 | PDIA3 | −0.051 | 0.884 | Cytoplasm | peptidase |
| Scinderin | SCIN | 0.028 | 0.221 | Cytoplasm | other |
| Alström syndrome protein 1, centrosome and basal body associated protein | ALMS1 | 0.18 | 0.572 | Cytoplasm | other |
| Histone H3.4 | HIST3H3 | 0.64 | 0.153 | Nucleus | other |
| Myeloperoxidase | MPO | 0.925 | 0.886 | Cytoplasm | enzyme |
| Secretoglobin family 2A member 1 | SCGB2A1 | 5.32 | 0.0008*** | Extracellular Space | other |
Note. Mothers showed higher spectral counts than children for 7/17 hair proteins (shaded blue), although children had higher spectral counts for SCGB2A1 (shaded orange). Of these, SCGB2A1 showed the most prominent results, with >5-fold differences from the mothers. Significance was based on Kruskal-Wallis ANOVA with post hoc Benjamini Hochberg corrections for multiple comparisons (*p-value ≤ 0.05, **p-value ≤ 0.01, ***p-value ≤ 0.001).