Fig 6. Cellular compartment size determines the time delay for the inversely out-of-phase Ca²⁺-cAMP oscillation.

(A) The Ca²⁺ and cAMP dynamics for a double-width compartment. Dynamics on the AKAP/AC nanodomain (i) and at the edge of the compartment (ii) are shown. (B-C) Same plots as (A) except the compartment size. The compartment is doubled in height in (B) and doubled in both height and width in (C). (D) The in-phase and inversely out-of-phase oscillations in (A-C). (E) The time delay in (A-C) as a function of the distance x to the nanodomain. The lower panel shows the magnified view of the Ca²⁺ and cAMP dynamics when x is close to the critical value, which is defined as the time when the transition of time delay occurs.