Figure 1.

The schematic representation of the study design for the interventions and behavioral tests

After 2 weeks of acclimatization, 33 male Wistar rats were randomly divided into six main groups (n = 5 per group), and a group (n = 3) to approve Aꞵ-induced AD induction. Afterward, the animals were subjected to main interventions for six weeks, followed by the MWM test. At the end point of the experiment, the hippocampus tissues were collected for histopathological and western blot analysis.

AL: Alzheimer’s group; CNT: Control group; HIIT: High-intensity interval training; CBD: Cannabidiol; MWM: Morris water maze