Table 1.

Baseline data of patients with water diuresis

Patient No.	Baseline Data						Water Diuresis Manifestation Time from Correction Start (h)	Infusate and Fluid Loss Formula Use	Correction Methods until Water Diuresis Manifestation	Before Water Diuresis Manifestation
	Age (yr)	Sex	Body Weight (kg)	s[Na] (mEq/L)	Hyponatremia Cause	Hyponatremia Symptom				s[Na]bef (mEq/L)	UVbef (ml/h)	u[Na+K]bef (mEq/L)	EFWCbef (ml/h)
1	65	Female	40.0	117	Unidentified	Coma	6	−	HTS (RBI), NS	119	90	51.7	51
2	70	Female	29.6	112	SIAD (vaccine stress)	Nausea, headache	9	+	HTS (RBI)	118	55	106.3	5
3	82	Male	59.9	107	SIAD (surgery stress)	Coma	13	−	HTS (SCI)	109	33	91.3	5
4	43	Male	65.0	104	Oral DDAVP	Nausea	3	−	D5W	105	N/A	59.4	N/A
5	92	Female	52.6	108	SIAD (stomacache)	Nausea, general weakness	5	+	NS	109	270	110	−2
6	54	Male	61.4	108	Primary polydipsia	Drowsiness, general weakness	3	+	D5W	108	60	11.2	54
7	61	Male	60.7	111	Primary polydipsia	Seizure, coma	4	+	HTS (RBI), NS, D5W	115	380	104	36
8	87	Female	43.1	114	Hypovolemic	Nausea	12	+	NS	115	10	14.3	9
9	55	Female	39.0	120	Primary polydipsia+SNRI	Seizure, coma	12	+	HTS (RBI, SCI)	131	117	57.7	65
10	93	Female	43.7	111	SIAD (rib fracture)	Unsteady gait	6	+	NS	112	650	86.8	146
11	51	Male	40.3	112	Unidentified	Drowsiness, general weakness	2	−	HTS (SCI)	116	N/A	46.5	N/A
12	53	Male	70.6	116	Primary polydipsia+thiazide	Coma, vomiting	2	−	D5W	116	N/A	49.7	N/A
13	51	Male	60.0	111	Acute heart failure	Drowsiness	6	+	HTS (SCI), LD	110	182	82.7	45
14	71	Female	56.3	110	Primary polydipsia+thiazide	Drowsiness	1	+	HTS (RBI, SCI)	112	N/A	N/A	N/A
15	74	Male	55.0	112	SIAD (herpes zoster pain)	Vomiting	22	+	NS	115	10	31.7	7
16	49	Female	42.2	113	Primary polydipsia	Vomiting	1	+	NS	113	N/A	N/A	N/A
17	66	Male	44.5	110	Hypovolemic+SNRI	Drowsiness, unsteady gait	3	+	HTS (SCI)	112	40	48.2	23
18	49	Female	49.5	115	Carbamazepine	Drowsiness	13	−	NS, D5W	118	93	111.4	5
19	84	Female	68.8	117	Oral DDAVP	Unsteady gait	10	−	HTS (SCI), D5W	121	100	54.7	55
20	73	Male	35.5	116	Thiazide	Drowsiness	19	+	NS, D5W	121	63	73.8	25
21	70	Female	44.0	112	Hypovolemic	Coma	34	−	NS	122	77	19.1	65
22	47	Male	44.4	99	Primary polydipsia	Drowsiness	2	−	NS	99	130	52.3	61
23	71	Male	47.4	110	Hypovolemic	General weakness, fatigue	4	+	NS, LD	112	400	79.6	116
24	97	Female	37.7	107	SIAD (stomach ache)	Vomiting	6	+	HTS (RBI, SCI), NS	115	20	118.8	−1
25	74	Female	29.8	109	Hypovolemic	Vomiting	4	+	HTS (RBI), D5W	116	250	80.4	77
26	80	Female	62.2	114	Primary polydipsia	Nausea, unsteady gait	3	+	NS	115	N/A	61.2	N/A
27	79	Male	53.6	103	Thiazide	Nausea	40	+	HTS (RBI, SCI), NS	116	77	60.5	37
28	84	Female	40.3	107	Hypovolemic+SNRI	Nausea	30	+	HTS (RBI), NS, D5W	117	53	56.9	27
29	84	Male	49.4	110	SIAD (arthralgia)	Nausea	15	+	HTS (RBI), NS, D5W	116	75	38	50
30	78	Female	44.7	108	Hypovolemic	Vomiting	2	+	HTS (RBI), D5W	112	230	60.3	106
Median	71		46.1	111			6			115	84	59.9	41
IQR	54–83		40.3–59.9	108–114			3–13			112–117	54–218	48.6–85.8	8–64

D5W, dextrose 5% in water; DDAVP, desmopressin acetate; EFWC, electrolyte-free water clearance; HTS, hypertonic saline; IQR, interquartile range; LD, loop diuretics; N/A, not applicable; NS, normal saline; RBI, rapid bolus infusion; SCI, slow continuous infusion; SIAD, syndrome of inappropriate antidiuresis; s[Na], serum sodium concentration; SNRI, serotonin noradrenaline reuptake inhibitor; u[Na+K], urinary sodium plus potassium; UV, urine volume.