Table 3.
Association of dialysate bicarbonate with any arrhythmia—session to session models (repeated measures logistic regression)
| Model | DBIC (mEq/L) |
n/N P Valuea |
|||
|---|---|---|---|---|---|
| <35 versus 35 OR (95% CI) n/N |
>35 versus 35 OR (95% CI) n/N |
<35 versus >35 OR (95% CI) n/N |
|||
| Arrhythmia subtype | |||||
| CSA | Unadjusted | 1.68 (0.49 to 5.72) 87/816 versus 56/1552 |
1.22 (0.41 to 3.58) 78/1287 versus 56/1552 |
1.38 (0.36 to 5.23) 87/816 versus 78/1287 |
221/3655 0.71 |
| Model 1 | 2.00 (0.55 to 7.22) 87/795 versus 56/1552 |
1.01 (0.32 to 3.16) 75/1181 versus 56/1552 |
1.99 (0.37 to 10.76) 87/795 versus 75/1181 |
218/3528 0.57 |
|
| Model 2 | 4.22 (0.92 to 19.33) 46/249 versus 29/549 |
1.68 (0.51 to 5.51) 41/388 versus 29/549 |
2.52 (0.37 to 17.13) 46/249 versus 41/388 |
116/1186 0.13 |
|
| Exploratory model | 3.28 (0.66 to 16.39) 44/240 versus 29/548 |
1.65 (0.49 to 5.60) 41/388 versus 29/548 |
1.98 (0.26 to 15.29) 44/240 versus 41/388 |
114/1176 0.24 |
|
| RCA | Unadjusted | 0.43 (0.09 to 2.10) 271/816 versus 533/1552 |
0.61 (0.25 to 1.51) 587/1287 versus 533/1552 |
0.71 (0.16 to 3.20) 271/816 versus 587/1287 |
1391/3655 0.44 |
| Model 1 | 0.41 (0.06 to 2.67) 265/795 versus 533/1552 |
0.58 (0.24 to 1.38) 541/1181 versus 533/1552 |
0.72 (0.10 to 4.95) 265/795 versus 541/1181 |
1339/3528 0.35 |
|
| Model 2 | 0.85 (0.15 to 4.67) 86/249 versus 173/549 |
1.25 (0.51 to 3.07) 193/388 versus 173/549 |
0.68 (0.10 to 4.54) 86/249 versus 193/388 |
452/1186 0.87 |
|
| Exploratory model | 0.91 (0.16 to 5.07) 84/240 versus 173/548 |
1.47 (0.58 to 3.71) 193/388 versus 173/548 |
0.62 (0.09 to 4.24) 84/240 versus 193/388 |
450/1176 0.71 |
|
| RCA subtypes | |||||
| Reviewer-confirmed atrial arrhythmia | Unadjusted | 0.45 (0.13 to 1.54) 238/816 versus 421/1552 |
0.77 (0.43 to 1.39) 454/1287 versus 421/1552 |
0.58 (0.18 to 1.83) 238/816 versus 454/1287 |
1113/3655 0.41 |
| Model 1 | 0.60 (0.11 to 3.25) 235/795 versus 421/1552 |
0.61 (0.35 to 1.09) 412/1181 versus 421/1552 |
0.98 (0.17 to 5.50) 235/795 versus 412/1181 |
1068/3528 0.23 |
|
| Model 2 | 0.98 (0.19 to 5.10) 73/249 versus 139/549 |
0.78 (0.33 to 1.84) 141/388 versus 139/549 |
1.25 (0.19 to 8.11) 73/249 versus 141/388 |
353/1186 0.85 |
|
| Exploratory model | 1.00 (0.19 to 5.29) 71/240 versus 139/548 |
0.86 (0.36 to 2.07) 141/388 versus 139/548 |
1.16 (0.18 to 7.55) 71/240 versus 141/388 |
351/1176 0.95 |
|
| Reviewer-confirmed ventricular arrhythmia | Unadjusted | 1.94 (0.49 to 7.75) 117/816 versus 108/1552 |
2.33 (0.54 to 10.01) 143/1287 versus 108/1552 |
0.83 (0.20 to 3.42) 117/816 versus 143/1287 |
368/3655 0.48 |
| Model 1 | 2.44 (0.75 to 7.93) 116/795 versus 108/1552 |
2.22 (0.60 to 8.21) 140/1181 versus 108/1552 |
1.10 (0.28 to 4.33) 116/795 versus 140/1181 |
364/3528 0.27 |
|
| Model 2 | 1.71 (0.62 to 4.69) 34/249 versus 38/549 |
2.31 (0.74 to 7.20) 53/388 versus 38/549 |
0.74 (0.23 to 2.36) 34/249 versus 53/388 |
125/1186 0.32 |
|
| Exploratory model | 1.45 (0.53 to 3.97) 34/240 versus 38/548 |
2.47 (0.75 to 8.13) 53/388 versus 38/548 |
0.59 (0.17 to 1.99) 34/240 versus 53/388 |
125/1176 0.33 |
|
Model 1 adjusted for age, sex, race, dialysis vintage, and vascular access. CSA, clinically significant arrhythmia; DBIC, dialysate bicarbonate; n/N, number of sessions with event/number of sessions; OR, odds ratio; RCA, reviewer confirmed arrhythmia.
Model 2 adjusted for age, sex, race, dialysis vintage, vascular access, and prehemodialysis serum bicarbonate.
Exploratory model adjusted for age, sex, race, dialysis vintage, vascular access, prehemodialysis serum bicarbonate, prehemodialysis serum potassium, and dialysate potassium levels.
a
Overall P value from repeated measures model F test.