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. 2024 Oct 30;18:1486740. doi: 10.3389/fncel.2024.1486740

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Copyright © 2024 Manickam, Maity, Murali, Gawande, Stothert, Batalkina, Cardona and Kaur.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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sFKN peptide modulates cochlear inflammation profile after NICS. Luminex assay-based quantification of the levels of cytokines (A) IFN-β, (B) IL-2, (C) IL-6, (D) IL-23, (E) IL-22, (F) IL-10, and (G) IL-33 in cochlear lysate from FKN WT mice subjected to either no-noise (NNE) or noise-exposed, then TT injected with vehicle at 1-day post-exposure (NE; vehicle) or noise-exposed and TT injected with sFKN peptide at 1-day post-exposure (NE; sFKN). N = 3–4 biological replicates per experimental group. Each biological sample was a pool of five cochleae run in triplicate. Values are means ± SD. *p < 0.05, ****p < 0.001, NNE vs. NE; vehicle or NE; sFKN vs. NE; vehicle. There was no significant difference in the means between NNE and NE; sFKN experimental groups. One-way ANOVA, Dunnett’s multiple comparison test.