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. 2024 Oct 30;15:1436561. doi: 10.3389/fphar.2024.1436561

TABLE 4.

Causes of DRPs.

Categories of causes Number of cases/case Proportion/%
Prescribing and drug selection 51 38.35
C1 Drug selection 26 19.55
C1.1 Inappropriate drug according to guidelines/formulary 14 10.53
C1.2 No indication for drug 2 1.50
C1.3 Inappropriate combination of drugs, or drugs and herbal medications, or drugs and dietary supplements 2 1.50
C1.4 Inappropriate duplication of the therapeutic group or active ingredient 5 3.76
C1.5 No or incomplete drug treatment despite existing
indication
3 2.26
C3 Dose selection 25 18.80
C3.1 Drug dose too low 4 3.01
C3.2 Drug dose of a single active ingredient too high 9 6.77
C3.3 Dosage regimen not frequent enough 3 2.26
C3.4 Dosage regimen too frequent 8 6.02
C3.5 Dose timing instructions wrong, unclear, or missing 1 0.75
Disp 5 3.76
C5 Dispensing 5 3.76
C5.2 Necessary information not provided or incorrect advice provided 5 3.76
Use 77 57.89
C7 Patient related 42 31.58
C7.1 Patient intentionally uses/takes less drug than prescribed or does not take the drug at all for whatever reason 18 13.53
C7.3 Patient abuses drug (unregulated overuse) 1 0.75
C7.4 Patient decides to use an unnecessary drug 2 1.50
C7.7 Inappropriate timing or dosing intervals 17 12.78
C7.8 Patient unintentionally administers/uses the drug in a
wrong way
4 3.01
C8 Patient transfer-related 11 8.27
C8.1 Medication reconciliation problem 11 8.27
C9 Other 24 18.05
C9.1 No or inappropriate outcome monitoring (incl. TDM) 1 0.75
C9.2 Other cause; specify 20 15.04
C9.3 No obvious cause 3 2.26
Total 133 100.00