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. 2024 Oct 30;15:1481753. doi: 10.3389/fimmu.2024.1481753

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Copyright © 2024 Fan, Chen, Wu, Liang, Shen and Miao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of TFF1 knockdown on tumor growth, survival, and apoptosis in a subcutaneous tumor model in mice. (A) Subcutaneous tumors after injection of siTFF1-1 and siNC. (B) Kaplan-Meier survival curves show that the survival rate of mice in the siTFF1-1 group was significantly higher than that in the control group (siNC). (C) Tumor weight was significantly reduced after TFF1 knockdown. (D) TFF1 knockdown significantly inhibited the increase in tumor volume. (E) Ki67 immunohistochemical staining shows that cell proliferation was significantly reduced in the siTFF1-1 group compared to the control group. (F) TUNEL fluorescent staining shows a significantly higher proportion of apoptotic cells in the siTFF1-1 group compared to the control group. (G, H) Quantified percentages of Ki67-positive (G) and TUNEL-positive (H) cells per field. Data are presented as mean ± standard deviation. **p < 0.01, ***p < 0.001, ****p < 0.0001 indicate statistically significant differences compared to the siNC group.