Central Illustration.

Vital Exhaustion, Elevated Cardiac Biomarkers, and Cardiovascular Risk

(A) Severe symptoms of vital exhaustion were associated with increased Risk of elevated high-sensitivity troponin T (hs-TnT), N-terminal pro-B-type natriuretic peptide (NT-proBNP), and high-sensitivity c-reactive protein (hs-CRP). ORs and 95% CIs were calculated using multivariable logistic regression to account for variables listed below. (B) Forest plots depict HRs that represent the association of vital exhaustion severity in the setting of nonelevated or elevated biomarker levels with incident cardiovascular events including myocardial infarction (MI), stroke, or heart failure (HF) hospitalization over a 10-year follow-up period. Adults with nonelevated biomarker levels and low symptoms of vital exhaustion were used as the reference categories. HRs were calculated using cox proportional hazard models. Error bars represent 95% CIs. All statistical models were adjusted for age, sex, race, education level, current smoking status, current drinking status, body mass index, systolic and diastolic blood pressure, hypertension, diabetes status, estimated glomerular filtration rate, total cholesterol level, low-density lipoprotein cholesterol level, high-density lipoprotein cholesterol level, and lipid-lowering medication use.