Table 1.
Baseline Characteristics of Participants Without a History of Cardiovascular Disease by Vital Exhaustion Quartiles
| MVEQ Score Quartile |
P Value | ||||
|---|---|---|---|---|---|
| 0-4 (Low) (n = 3,871, 33.5%) | 5-8 (Mild) (n = 2,319, 20.1%) | 9-15 (Moderate) (n = 2,720, 23.6%) | 16-42 (Severe) (n = 2,632, 22.8%) | ||
| Age, y | 56.8 ± 5.6 | 57.2 ± 5.7 | 57.3 ± 5.7 | 57.3 ± 5.8 | 0.21 |
| Female | 1,622 (41.9) | 1,298 (55.9) | 1,754 (64.5) | 1,911 (72.6) | <0.001 |
| Black race | 700 (18.1) | 524 (22.6) | 721 (26.5) | 803 (30.5) | <0.001 |
| Education level | <0.001 | ||||
| Less than high school | 492 (12.8) | 383 (16.6) | 551 (20.3) | 826 (31.5) | |
| High school | 1,516 (39.2) | 1,003 (43.2) | 1,184 (43.7) | 1,156 (43.9) | |
| At least some college | 1,856 (48.0) | 931 (40.2) | 979 (36.0) | 646 (24.5) | |
| Current smoker | 681 (17.7) | 469 (20.2) | 645 (23.7) | 684 (26.0) | <0.001 |
| Current drinker | 2,505 (64.7) | 1,397 (60.2) | 1,521 (55.9) | 1,284 (48.8) | <0.001 |
| BMI, kg/m2 | 27.3 ± 4.6 | 27.7 ± 5.1 | 27.9 ± 5.4 | 28.8 ± 6.1 | <0.001 |
| Systolic BP, mm Hg | 120.2 ± 17.5 | 121.7 ± 18.2 | 120.9 ± 18.6 | 121.2 ± 19.7 | <0.001 |
| Diastolic BP, mm Hg | 72.5 ± 9.8 | 72.6 ± 10.1 | 71.7 ± 10.4 | 71.7 ± 10.4 | 0.001 |
| Total cholesterol, mg/dL | 207.4 ± 37.1 | 209.3 ± 39.2 | 209.7 ± 38.3 | 211 ± 41.1 | <0.001 |
| LDL-C, mg/dL | 132.9 ± 34.5 | 132.9 ± 37.0 | 132.2 ± 36.6 | 133.2 ± 38.3 | <0.001 |
| HDL-C, mg/dL | 48.7 ± 16.2 | 50.7 ± 17.3 | 51.2 ± 17.2 | 51.5 ± 17.1 | <0.001 |
| Hypertension | 1,111 (28.7) | 747 (32.1) | 907 (33.3) | 981 (37.2) | <0.001 |
| Diabetes mellitus | 411 (10.6) | 275 (11.8) | 375 (13.8) | 449 (17.0) | <0.001 |
| eGFR, mL/min/1.73 m2 | 96.2 ± 13.9 | 96.6 ± 14.6 | 97.4 ± 15.4 | 97.9 ± 16.7 | <0.001 |
| LLT within past 2 weeks | 203 (5.2) | 109 (4.7) | 145 (5.3) | 142 (5.4) | 0.67 |
| hs-TnT, ng/L | 3 (1.5, 6) | 1.5 (1.5, 6) | 1.5 (1.5, 6) | 1.5 (1.5, 6) | 0.17 |
| hs-TnT ≥3 ng/L | 1,948 (50.1) | 1,123 (48.2) | 1,265 (46.2) | 1,219 (46.1) | 0.003 |
| hs-TnT ≥13 ng/L | 152 (3.9) | 110 (4.9) | 122 (4.7) | 160 (6.4) | 0.001 |
| NT-proBNP, pg/mL | 43.0 (23.2, 77.7) | 49.4 (26.2, 86.7) | 51.2 (27.8, 92.8) | 56.6 (30.2, 102.6) | <0.001 |
| NT-proBNP ≥125 pg/mL | 430 (11.1) | 323 (13.9) | 402 (14.7) | 483 (18.3) | <0.001 |
| hs-CRP, mg/L | 1.8 (0.89-3.6) | 2.04 (0.98, 4.29) | 2.36 (1.09, 4.95) | 2.7 (1.2, 5.9) | <0.001 |
| hs-CRP, ≥2 mg/L | 1,777 (45.8) | 1,179 (50.6) | 1,503 (55.0) | 1,617 (61.2) | <0.001 |
Values are mean ± SD, n (%), or median (25th, 75th percentile).
BMI = body mass index; BP = blood pressure; eGFR = estimated glomerular filtration rate; HDL-C = high-density lipoprotein cholesterol; hs-CRP = high-sensitivity C-reactive protein; hs-TnT = high-sensitivity troponin-T; LDL-C = low-density lipoprotein cholesterol; LLT = lipid-lowering therapy; MVEQ = Maastricht Vital Exhaustion Questionnaire; NT-proBNP = N-terminal pro–B-type natriuretic peptide.