Table 4.

Association of Vital Exhaustion and Elevated Biomarkers With All-Cause Mortality During 10-Y Follow-Up

	Nonelevated Biomarker Levels				Elevated Biomarker Levels				P Value for Interactiona
	Low MVEQ [Reference]	Mild MVEQ	Moderate MVEQ	Severe MVEQ	Low MVEQ	Mild MVEQ	Moderate MVEQ	Severe MVEQ
hs-TnT	1.00	1.18 (0.94-1.47, P = 0.14)	1.36 (1.11-1.67, P < 0.01)	1.57 (1.27-1.93, P < 0.01)	2.09 (1.37-3.21, P < 0.01)	2.76 (1.82-4.20, P < 0.01)	2.51 (1.68-3.76, P < 0.01)	3.81 (2.76-5.25, P < 0.01)	0.72
NT-proBNP	1.00	1.23 (0.97-1.57, P = 0.07)	1.32 (1.05-1.66, P = 0.02)	1.54 (1.23-1.94, P < 0.01)	2.21 (1.61-3.04, P < 0.01)	2.52 (1.79-3.55, P < 0.01)	3.22 (2.39-4.35, P < 0.01)	4.04 (3.08-5.30, P < 0.01)	0.70
hs-CRP	1.00	1.23 (0.89-1.71, P = 0.20)	1.34 (0.98-1.83, P = 0.06)	1.75 (1.29-2.39, P < 0.01)	1.42 (1.08-1.88, P = 0.01)	1.70 (1.27-2.27, P < 0.01)	1.94 (1.47-2.56, P < 0.01)	2.32 (1.77-3.06, P < 0.01)	0.97

Values are HR (95% CI, P value). HRs were adjusted for age, sex, race, education level, current smoking status, current drinking status, body mass index, systolic and diastolic blood pressure, hypertension, diabetes status, estimated glomerular filtration rate, total cholesterol level, low-density lipoprotein cholesterol level, high-density lipoprotein cholesterol level, and lipid-lowering medication use. Symptoms of vital exhaustion were categorized as follows: 1) no symptoms (MVEQ score 0-4); 2) mild symptoms (MVEQ score 5-8); 3) moderate symptoms (MVEQ score 9-15); and severe symptoms (MVEQ score ≥16). Nonelevated biomarker levels indicate plasma levels below the following thresholds: hs-TnT <13 ng/L; NT-proBNP <125 pg/mL; hs-CRP <2 mg/L. Elevated biomarker levels indicate plasma levels above the following thresholds: hs-TnT ≥13 ng/L; NTproBNP ≥125 pg/mL; hs-CRP ≥2 mg/L.

Abbreviations as in Table 1.

^aP for interaction between MVEQ quartiles and presence of elevated biomarker levels.