Table 1.
Clinical characteristics of ICC patients.
| Variate | Total | NLR < 2.36 | NLR ≥ 2.36 | p- value |
|---|---|---|---|---|
| (n = 360) | (n = 101) | (n = 259) | ||
| Age (y) | 58.6 ± 9.3 | 57.8 ± 9.3 | 58.9 ± 9.3 | 0.681 |
| TBIL (μmol/L) | 57.2 ± 31.9 | 37.2 ± 24.7 | 63.2 ± 34.8 | 0.003 |
| ALB (g/L) | 39.4 ± 5.9 | 39.9 ± 5.9 | 40.2 ± 16.2 | 0.337 |
| A/G | 1.6 ± 0.4 | 1.6 ± 0.3 | 1.7 ± 2.8 | 0.429 |
| ALT (U/L) | 74.5 ± 52.6 | 73.8 ± 52.1 | 79.2 ± 53.0 | 0.723 |
| AST (U/L) | 61.0 ± 48.2 | 60.2 ± 50.3 | 61.1 ± 41.7 | 0.435 |
| ALP (U/L) | 197.9 ± 175.5 | 195.9 ± 185.1 | 202.9 ± 167.0 | 0.845 |
| GGT (U/L) | 270.0 ± 212.6 | 232.0 ± 192.2 | 280.8 ± 220.5 | 0.187 |
| PT (s) | 11.2 ± 1.4 | 11.1 ± 1.4 | 11.2 ± 1.4 | 0.393 |
| AFP (ng/mL) | 15.4 ± 77.3 | 11.9 ± 35.3 | 16.7 ± 88.4 | 0.453 |
| CEA (ng/mL) | 27.2 ± 7.8 | 10.3 ± 5.7 | 43.9 ± 12.4 | 0.014 |
| CA199 (U/mL) | 425.0 ± 233.5 | 324.1 ± 186.8 | 455.8 ± 248.6 | 0.213 |
| CA125 (U/mL) | 90.1 ± 50.2 | 91.1 ± 54.7 | 88.5 ± 48.1 | 0.207 |
| LMR | 3.0 ± 1.5 | 3.8 ± 1.7 | 2.6 ± 1.3 | <0.001 |
| SII | 999.2 ± 944.7 | 573.0 ± 559.3 | 1095.0 ± 1086.9 | <0.001 |
| NLR | 3.9 ± 1.5 | 1.5 ± 0.6 | 4.9 ± 2.4 | <0.001 |
| MTD | ||||
| >5 cm | 168 (45.7%) | 47 (46.5%) | 121 (46.7%) | 0.535 |
| <5 cm | 192 (53.3%) | 54 (53.5%) | 138 (53.3%) | |
| Gender | ||||
| Male | 176 (48.9%) | 49 (48.5%) | 127 (49.0%) | 0.512 |
| Female | 184 (51.1%) | 52 (51.5%) | 132 (51.0%) | |
| Hepatolithiasis | ||||
| Yes | 151 (41.9%) | 36 (35.6%) | 115 (44.4%) | 0.081 |
| No | 209 (58.1%) | 65 (64.4%) | 144 (55.6%) | |
| HBV carrier | ||||
| Yes | 65 (18.1%) | 21 (20.8%) | 44 (17.0%) | 0.243 |
| No | 295 (81.9%) | 80 (79.2%) | 215 (83.0%) | |
| Child-Pugh | ||||
| A | 329 (91.4%) | 96 (95.0%) | 233 (90.0%) | 0.086 |
| B | 31 (8.6%) | 5 (5.0%) | 26 (10.0%) | |
| Vascular invasion | ||||
| Yes | 120 (33.3%) | 34 (33.7%) | 86 (33.2%) | 0.514 |
| No | 240 (66.7%) | 67 (66.3%) | 173 (66.8%) | |
| Local invasion | ||||
| Yes | 107 (29.7%) | 35 (34.7%) | 72 (27.8%) | 0.125 |
| No | 253 (70.3%) | 66 (65.3%) | 187 (72.2%) | |
| Nerve invasion | ||||
| Yes | 141 (39.2%) | 28 (27.7%) | 113 (43.6%) | 0.004 |
| No | 219 (60.8%) | 73 (72.3%) | 146 (56.4%) | |
| Blood transfusion | ||||
| Yes | 58 (16.1%) | 8 (8.0%) | 50 (19.3%) | 0.005 |
| No | 302 (83.9%) | 93 (92.0%) | 209 (80.7%) | |
| Poorly differentiation | ||||
| No | 182 (50.6%) | 44 (43.6%) | 138 (53.3%) | 0.062 |
| Yes | 178 (49.4%) | 57 (56.4%) | 121 (46.7%) | |
| TNM staging | ||||
| I, II | 214 (59.4%) | 46 (45.5%) | 100 (38.6%) | 0.139 |
| III | 146 (40.6%) | 55 (54.5%) | 159 (61.4%) | |
| Complications Grade | ||||
| I, II | 298 (82.8%) | 83 (82.2%) | 215 (83.0%) | 0.481 |
| III-V | 62 (17.2%) | 18 (17.8%) | 44 (17.0%) | |