Table 3.
Univariable and multivariate regression analyses of risk factors for neoplasm recurrence within 5 years after surgery in ICC patients.
| Variate | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| p- value | HR | 95%CI | p- value | HR | 95%CI | |
| Age > 60 y | 0.162 | 0.740 | 0.485–1.128 | |||
| TBIL>17.1 μmol/L | 0.731 | 0.924 | 0.587–1.452 | |||
| ALB<35 g/L | 0.426 | 1.217 | 0.750–1.972 | |||
| A/G < 1.5 | 0.335 | 1.231 | 0.807–1.878 | |||
| ALT>80 U/L | 0.645 | 1.148 | 0.638–2.066 | |||
| AST > 80 U/L | 0.555 | 1.231 | 0.617–2.457 | |||
| ALP > 135 U/L | <0.001 | 2.273 | 1.477–3.498 | 0.048 | 1.814 | 1.006–3.272 |
| GGT > 64 U/L | 0.128 | 1.425 | 0.903–2.248 | |||
| PT > 13 s | 0.013 | 2.280 | 1.194–4.354 | 0.025 | 2.587 | 1.127–5.941 |
| AFP > 25 ng/mL | 0.339 | 1.614 | 0.605–4.302 | |||
| CEA > 10 ng/mL | <0.001 | 5.121 | 3.116–8.415 | <0.001 | 5.506 | 2.945–10.295 |
| CA199 > 37 U/mL | 0.030 | 1.614 | 1.047–2.488 | 0.764 | 0.913 | 0.504–1.655 |
| CA125 > 35 U/mL | 0.161 | 1.387 | 0.878–2.190 | |||
| LMR > 3.71 | <0.001 | 2.642 | 1.601–4.360 | <0.001 | 4.283 | 2.250–8.155 |
| SII > 730.14 | 0.348 | 0.817 | 0.535–1.247 | |||
| NLR ≥ 2.36 | <0.001 | 2.986 | 1.886–4.730 | 0.001 | 2.733 | 1.510–4.948 |
| MTD > 5 cm | <0.001 | 0.403 | 0.262–0.621 | 0.029 | 0.535 | 0.305–0.939 |
| Gender, Male | 0.272 | 1.267 | 0.831–1.932 | |||
| Hepatolithiasis, Yes | <0.001 | 3.119 | 1.976–4.926 | 0.062 | 1.779 | 0.305–0.939 |
| HBV carrier, Yes | 0.106 | 0.640 | 0.373–1.099 | |||
| Child-Pugh, B | 0.343 | 1.461 | 0.667–3.202 | |||
| Vascular invasion, Yes | 0.004 | 0.521 | 0.334–0.813 | 0.003 | 0.374 | 0.195–0.717 |
| Local invasion, Yes | 0.655 | 0.901 | 0.569–1.425 | |||
| Nerve invasion, Yes | 0.018 | 1.704 | 1.096–2.649 | 0.654 | 0.873 | 0.483–1.580 |
| Blood transfusion, Yes | <0.001 | 7.391 | 3.081–17.726 | <0.001 | 6.298 | 2.265–17.513 |
| PD, Yes | 0.062 | 1.497 | 0.980–2.287 | |||
| TNM staging, III | <0.001 | 2.644 | 1.710–4.089 | <0.001 | 3.439 | 1.857–6.367 |
| Complications Grade, III-IV | 0.862 | 1.042 | 0.652–1.667 | |||
Bold values means statistically significant.