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. 2024 Nov 12;15:9801. doi: 10.1038/s41467-024-52528-7

Fig. 5. Plasma concentration of circulating cytokines reveals downregulation of chemochines associated with TAM infiltration and angiogenesis upon entinostat exposure.

Fig. 5

a change in plasma concentration of MCP-1 (p = 0.007), sCD40L (p = 0.024), Eoxtaxin (p = 0.033), MDC (p = 0.033), and MIP-1b (0.046); b change in plasma concentration of IP-10 (p = 0.002) and IL-6 (p = <0.001). P-values from paired two-sided Wilcoxon test between time points. Statistically significant P value is shown as follows: *P < 0.05. N = 20 paired patient samples between baseline and C1D1 and and n = 4 paired samples between C1D1 and C2D1. Source data are provided as a Source Data file. IL-6, interleukin 6; IP10, interferon γ-induced protein 10 kDa; MCP-1, Monocyte Chemoattractant Protein-1; MDC, Macrophage-derived chemokine; MIP-1b, Macrophage inflammatory protein-1 beta; sCD40L, soluble CD40 Ligand; NR, non responders; R, responders.