Table 4.
Test accuracy and logistic regression
| Test accurancy | ||||
|---|---|---|---|---|
| Reader 1 | ||||
| Node-RADS | Sensitivity (CI 95%) | Specificity (CI 95%) | PPV (CI 95%) | NPV (CI 95%) |
| > 1 | 97.9 (92.4%–99.7%) | 71.4 (61.4%–80.1%) | 76.7 (70.6%–81.8%) | 97.2 (89.8%–99.3%) |
| > 2 | 95.7 (89.5%–98.8%) | 89.8 (82%–95%) | 90 (83.3%–94.2%) | 95.7 (89.4%–98.3%) |
| > 3 | 66 (55.5%–75.4%) | 100 (96.3%–100%) | 100 (94.2%–100%) | 75.4 (69.8–80.2%) |
| > 4 | 31.9 (22.7%–42.3%) | 100 (96.3%–100%) | 100 (88.4%–100%) | 60.5 (57.1%–73.3%) |
| Reader 2 | ||||
| Node-RADS | Sensitivity (CI 95%) | Specificity (CI 95%) | PPV (CI 95%) | NPV (CI 95%) |
| > 1 | 93.6 (86.6%–97.6%) | 69.4 (59.3%–78.3%) | 74.6 (68.4%–79.9%) | 91.9 (83.8%–96.1%) |
| > 2 | 89.4 (81.3%–94.8%) | 87.8 (79.6%–93.5%) | 87.5 (80.4%–92.3%) | 89.6 (82.6%–93.9%) |
| > 3 | 57.4 (46.8%–67.6%) | 100 (96.3%–100%) | 100 (93.4%–100%) | 71 (65.9%–75.6%) |
| > 4 | 31.9 (22.7%–42.3%) | 100 (96.3%–100%) | 100 (88.4%–100%) | 60.5 (57.1%–63.7%) |
| Reader 3 | ||||
| Node-RADS | Sensitivity (CI 95%) | Specificity (CI 95%) | PPV (CI 95%) | NPV (CI 95%) |
| > 1 | 95.7 (89.5%–98.8%) | 64.3 (54%–73.7%) | 72 (66.3%–77%) | 94 (85.6%–97.6%) |
| > 2 | 89.4 (81.3%–94.8%) | 84.7 (76%–91.2%) | 84.8 (77.8%–90%) | 89.2 (82.1%–93.7%) |
| > 3 | 68.1 (57.7%–77.3%) | 96.9 (91.3%–99.4%) | 95.5 (87.4%–98.5%) | 76 (70.2%–81%) |
| > 4 | 36.2 (26.5%–46.7%) | 100 (96.3%–100%) | 100 (89.7%–100%) | 62 (58.4%–65.5%) |
| Univariate logistic regression | ||||
| OR (CI 95%) | p-value | |||
| Age | 0.966 (0.944–0.989) | 0.004 | ||
| cT stage | 2.495 (1.789–3.479) | < 0.001 | ||
| Node-R Reader 1 | 14.997 (6.769–33.228) | < 0.001 | ||
| Node-R Reader 2 | 6.988 (4.241–11.514) | < 0.001 | ||
| Node-R Reader 2 | 5.823 (3.729–9.094) | < 0.001 | ||
| Multivariate logistic regression (enter method) Reader 1 | ||||
| OR (CI 95%) | p-value | |||
| Age | 0.965 (0.919–1.014) | 0.155 | ||
| cT stage | 1.957 (1.005–3.813) | 0.048 | ||
| Node-RADS | 14.997 (6.769–33.228) | < 0.001 | ||
| Multivariate logistic regression (enter method) Reader 2 | ||||
| OR (CI 95%) | p-value | |||
| Age | 0.951 (0.913–0.990) | 0.015 | ||
| cT stage | 2.029 (1.005–3.813) | 0.007 | ||
| Node-RADS | 6.996 (4.059–12.060) | < 0.001 | ||
| Multivariate logistic regression (enter method) Reader 3 | ||||
| OR (CI 95%) | p-value | |||
| Age | 0.957 (0.919–0.996) | 0.031 | ||
| cT stage | 1.888 (1.133–3.146) | 0.015 | ||
| Node-RADS | 5.636 (3.492–9.097) | < 0.001 | ||
OR odds ratio, CI confidence interval