Fig. 3.

Observed RAPID3 MCID response and missing data in ITT population, and observed mean change from baseline in patients with data available. a RAPID3 change from baseline ≤ −3.8 (MCID) observed and missing data. b Observed RAPID3 mean score change from baseline. MMRM mixed-effect model for repeated measures, RAPID3 routine assessment of patient index data 3, Rx treatment, SE standard error. The mean and SE at each visit were calculated based on the observed data at the visit; the p values for a comparison between monotherapy and combination therapy were calculated using an MMRM approach that included the initial treatment regimen, visit, and initial treatment regimen-by-visit interaction as fixed effects and the baseline value as a covariate