TABLE 2.
Summary of representative recruiting, enrolling, active clinical trials involving topical hydrogels, hydrogel contact lenses, and hydrogel implants.
| Name (Company) | Indication | Hydrogel formulation | Drug delivered? | NCT number (Trial Phase) |
|---|---|---|---|---|
| Representative products—hydrogel implants in clinical trial | ||||
| BEAR Implant (Miach Orthopedics) | Anterior cruciate ligament injuries | Bovine collagen implant | No | NCT05398341 (not given) |
| Myriad Matrix, Myriad Morcells (Aroa Biosurgery Ltd.) | Abdominal Wound Dehiscence|Necrotizing Soft Tissue Infection|Lower Extremity Wound|Pilonidal Sinus|Anal Fistula|Hidradenitis Suppurativa|Pressure Injury | ECM implant | No | NCT05243966 (not given) |
| HANBIO BarriGel (HAN Biomedical Inc.) | Adhesion|Thyroid Diseases | Hyaluronic acid implant | No | NCT05036525 (NA) |
| BrachyGel (Brachy Foam, LLC) | Cervical cancer | PEG implant | No | NCT04499521 (NA) |
| DEXTENZA (Ocular Therapeutix, Inc.) | Vitreoretinal surgery, pain, inflammation | PEG implant | Yes, dexamethasone | NCT04371445 (Ph 4) and NCT04200651 (Ph 4) |
| AxoGuard (Axogen Corp.) | Symptomatic neuroma, chronic nerve pain | Porcine ECM implant | No | NCT03940963 (NA) and NCT04865679 (NA) |
| ESTYME (Symatese Aesthetics) | Bilateral breast augmentation | Silicone implant | No | NCT05336526 (NA) |
| Silimed (Silimed Industria de Implantes Ltda.) | Breast implant | Silicone implant | No | NCT03356132 (not given) |
| Motiva Implant (Motiva USA LLC) | Breast implant | Silicone implant | No | NCT03579901 (NA) |
| Representative products—topical hydrogels | ||||
| PTX‐022 (Palvella Therapeutics, Inc.) | Pachyonychia congenita, basal cell carcinomas in Gorlin syndrome patients | Topical carbomer 940 | No | NCT05643872 (Ph 3) and NCT04893486 (Ph 2) |
| TCP‐25 (Xinnate AB) | Blister skin wound | Topical hydroxyethylcellulose | No | NCT05378997 (Ph 1) |
| Catasyn (Synedgen, Inc.) | Superficial partial thickness burn | Topical hydroxypropylcellulose | No | NCT04601532 (Ph 4) |
| StrataMGT (Strataphama AG) | Genitourinary syndrome of menopause | Topical silicone | No | NCT05672901 (NA) |
| StrataXRT (Stratapharma AG) | Radiation dermatitis | Topical silicone | No | NCT05553392 (NA) |
| Suprasorb (Lohmann & Rauscher) | Ulcer | Topical alginate | No | NCT05646121 (not given) |
| RadiaAce (AceTech) | Breast cancer radiation dermatitis | Topical acemannan | No | NCT04481802 (NA) |
| QY211 (E‐nitiate Biopharmaceuticals Co., Ltd. | Atopic dermatitis | Topical carbomer 947 | No | NCT05843422 (Ph 1) |
| NanoDOX (NanoSHIFT LLC) | Wounds and injury | Topical carboxymethylcellulose | Yes, doxycycline | NCT05411484 (Ph 2) |
| NanoSALV (NanoTess, Inc.) | Ulcer | Topical cellulose | No | NCT05619237 (NA) |
| SynePure (Synedgen, Inc.) | Burn wounds | Topical chitosan | Yes, silver sulfadiazine | NCT05877638 (NA) |
| TTAX01 (Tissue Tech, Inc.) | Diabetic foot infection, non‐healing wound | Topical decellularized human placental umbilical cord tissue | No | NCT04450693 (Ph 3) and NCT04176120 (Ph 3) |
| Restrata, Apligraf (Acera Surgical, Inc.) | Diabetic foot ulcer, venous leg ulcer | Topical electrospun ECM | No | NCT04927702 (NA) |
| Juvia (FEMPHARMA Kft.) | Vaginal yeast infections | Topical hydroxyethylcellulose | Yes, zinc | NCT05895162 (NA) |
| KeraStat (KeraNetics, LLC) | Partial‐thickness burn | Topical keratin | No | NCT03564795 (NA) |
| BIAKOS (SeranaGropu, Inc.) | Wound of skin | Topical poloxamer407 | Yes, polyaminopropyl biguanide | NCT05107050 (NA) |
| Representative product—hydrogel stent | ||||
| XEN45 (Allergan/AbbVie) | Open‐angle glaucoma | Porcine collagen‐derived gelatin hydrogel stent | No | NCT05411198 (Ph 3) |
| Representative product—hydrogel coil | ||||
| HydroSoft (Microvention‐Terumo, Inc.) | Ruptured aneurysm | Vinyl polymer hydrogel coil | No | NCT03252314 (not given) |
Note: Trials are organized first by material form, then biomaterial composition.