TABLE 4.
Summary of recruiting, enrolling, and active clinical trials proposing new disease indications for hydrogel‐based dosage forms, delivery systems, or therapeutics.
| Name (sponsor company or university) | Indication | Route of administration | Hydrogel formulation | Drug delivered | ClinicalTrials.gov Identifier (Trial Phase) |
|---|---|---|---|---|---|
| KD Intra‐Articular® gel (Procare Health Iberia S.L.) | Hip, thumb, or ankle osteoarthritis | Intraarticular injection | Hyaluronic acid | No | NCT05275244 (not given) |
| Purastat (AdventHealth) | Esophageal stricture | Topical application to GI lesions via endoscope | Synthetic peptide | No | NCT05581173 (not given) |
| Bridge‐Enhanced ACL Restoration (BEAR®) (Miach Orthopedics) | Anterior cruciate ligament injuries | Surgical implant | Bovine collagen | No | NCT05398341 (not given) |
| ORISE gel (Portsmouth Hospitals NHS Trust, etc.) | Colorectal polyp | Submucosal injection during endoscopy | Poloxamer | No | NCT04886609 (not given) |
| Condrotide (Mastelli S.r.I, Latis S.r.I.) | Meniscus tear, meniscus lesion | Intraarticular and intrameniscal injection | Polynucleotide | No | NCT05322005 (NA) |
| DAC‐AE (Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France) | Hip prosthesis infection | Surgical implant | Hyaluronic acid and poly(lactic acid) | Yes, antibiotic | NCT04251377 (NA) |
| DAC, Novagenit SRL (Centre Hospitalier Universitaire de Saint Etienne, Ministry of Health, France) | Hip prosthesis infection | Surgical implant | Hyaluronic acid, poly‐lactic acid | Yes, antibiotic | NCT04251377 (NA) |
| Papilocare (Procare Health Iberia S.L., Adkoma Health Research) | Human papilloma virus, human papilloma virus infection, cervix lesion | Intravaginal injection via cannula | Hyaluronic acid, beta glucans | No | NCT04199078 (NA) |
| Axoguard Nerve Cap (Axogen Corp.) | Symptomatic neuroma, amputation, chronic nerve pain | Surgical implant | Porcine ECM | No | NCT04865679 (NA) |
| Axoguard Nerve Cap (Axogen Corp.) | Symptomatic neuroma, Morton's neuroma, chronic nerve pain | Surgical implant | Porcine ECM | No | NCT03940963 (NA) |
| GelStix (Ospedale Regionale di Lugano, Rijnstate Ziekenhuis, Arnhem, the Netherlands) | Degeneration of lumbar intervertebral disc | Intradiscal injection | Hydrolysed poly(acrylonitrile) | No | NCT02763956 (NA) |
| MectaShield (Medacta International SA) | Arthritis, traumatic arthritis, avascular necrosis | Surgical implant | Unknown | Yes, antibiotic | NCT05679232 (NA) |
| JointRep (Oligo Medic Pty Ltd. Mobius Medical Pty Ltd.) | Articular cartilage defect | Intraarticular injection | Chitosan | No | NCT04840147 (NA) |
| ADAM system (Contraline Inc.) | Azoospermia, oligospermia | Injection into vas deferens | Unknown | No | NCT05134428 (NA) |
| MateRegen (Chinese University of Hong Hong) | First trimester abortion, surgical abortion, miscarriage with afibrinogenemia | Intrauterine injection | Hyaluronic acid | No | NCT05360186 (NA) |
| Hyalobarrier Gel (Ghent University Hospital, etc.) | Infertility, uterine polyp uterine myoma, uterine adhesion, hysteroscopy, uterine septum | Intrauterine injection | Hyaluronic acid | No | NCT03880435 (NA) |
| Hyalobarrier Gel (Ghent University Hospital) | Myoma | Intrauterine injection | Hyaluronic acid | No | NCT05683041 (NA) |
| Hyalobarrier Gel (SciVision Biotech Inc) | Tissue adhesion in gynecologic surgery | Intrapelvic implant | Hyaluronic acid | No | NCT04063085 (NA) |
| Juvia (Fempharma Kft.) | Vaginal yeast infections | Topical application to vagina | Hydroxyethylcellulose | Yes, zinc | NCT05895162 (NA) |
| StrataMGT (Stratpharma AG) | Genitourinary syndrome of menopause | Topical application to vagina | Silicone | No | NCT05672901 (NA) |
| VersaWrap (University of Colorado, Denver) | Distal radius fracture, tendon rupture | Surgical Implant | Hyaluronic acid and alginate | No | NCT04976335 (NA) |
| HANBIO BarriGel (HAN Biomedical Inc.) | Adhesion, thyroid diseases | Surgical Implant | Hyaluronic acid | No | NCT05036525 (NA) |
| Embrace Hydrogel Embolic System (HES) (Instylla, Inc.) | Arterial bleeding in solid organs and peripheral arteries | Intraarterial injection | PEG | No | NCT05364502 (NA) |
| Hydrocoil (Seoul National University Hospital, etc.) | Ruptured aneurysm, intracranial aneurysm | Intracranial implant in Aneurysm | Unknown | No | NCT04988503 (NA) |
| ATX01 (Algo Therapeutix) | Chemotherapy‐induced peripheral neuropathy | Transdermal delivery | Unknown | Yes, amitriptyline hydrochloride | NCT05593614 (Ph II) |
| Androgel (University Hospital, Clermont‐Ferrand) | Hypermetabolism in ICU | Transdermal delivery | Carbomer 980 | Yes, testosterone | NCT03678233 (Ph II) |
| Androgel (VA Office of Research and Development) | Type 2 diabetes mellitus, hypogonadism | Transdermal delivery | Carbomer 980 | Yes, testosterone | NCT03887936 (Ph IV) |
| Juveena (Rejoini Inc.) | Intrauterine adhesion | Intrauterine injection | PEG | No | NCT05394662 (Ph III) |
| FORTESTA (Endo Pharmaceuticals) | Male hypogonadism, hypogonadotropic hypogonadism | Transdermal delivery | Carbomer | Yes, testosterone | NCT04456296 (Ph IV) |
Note: Trials are organized by phase.