Table 3.
Comparison of the levels of serum markers between different degrees of frailty groups
| Mild frailty group (n=26) | Moderate frailty group (n=20) | Severe frailty group (n=24) | F | P | |
|---|---|---|---|---|---|
| White blood cell count (×109/L) | 7.1±2.1 | 6.6±1.3 | 7.4±2.4 | 0.790 | 0.458 |
| Hemoglobin (g/L) | 128.9±26.8 | 129.9±4.5 | 116.3±13.0**,## | 4.103 | 0.021 |
| CRP (mg/L) | 1.7 (0.5-5.4) | 4.5 (0.5-13.1)* | 8.6 (3.3-53.7)**,## | 3.389 | 0.029 |
| Triglycerides (mmol/L) | 1.2±0.5 | 1.2±0.5 | 1.2±0.7 | 0.015 | 0.985 |
| Total cholesterol (mmol/L) | 3.7±1.2 | 4.0±0.7 | 3.5±0.7 | 1.826 | 0.227 |
| Low-density lipoprotein (mmol/L) | 2.2±1.0 | 2.5±0.7 | 2.0±0.7 | 2.701 | 0.075 |
| High-density lipoprotein (mmol/L) | 1.2±0.3 | 1.3±0.3 | 1.1±0.2 | 1.429 | 0.337 |
| D-dimer (mg/L) | 0.4 (0.3-0.9) | 0.7 (0.3-1.0) | 0.4 (0.2-0.9) | 2.297 | 0.108 |
| Albumin (g/L) | 32.6±3.6 | 33.7±3.5 | 33.5±3.0 | 0.688 | 0.506 |
| Globulin (g/L) | 26.1±3.6 | 28.7±4.9 | 29.0±5.2 | 3.042 | 0.054 |
| Total protein (g/L) | 58.7±4.6 | 62.4±7.3 | 61.6±6.6 | 2.385 | 0.100 |
| Bilirubin (μmol/L) | 13.2±8.3 | 12.4±5.3 | 12.8±7.8 | 0.072 | 0.931 |
| Total bile acid (μmol/L) | 8.0±5.1 | 6.4±5.3 | 7.3±5.0 | 0.180 | 0.836 |
| Urea nitrogen (mmol/L) | 4.5±1.3 | 4.8±2.1 | 5.5±2.2 | 1.887 | 0.160 |
| Creatinine (μmol/L) | 62.7±7.8 | 65.3±17.3 | 70.3±33.3 | 1.438 | 0.216 |
| Glucose (mmol/L) | 6.2±2.1 | 5.9±1.8 | 6.3±2.4 | 0.180 | 0.836 |
| HBA1C (%) | 6.3±1.3 | 6.5±1.3 | 7.4±2.5 | 1.978 | 0.148 |
| BNP (pg/ml) | 461.4 (229.3-1388.0) | 301.1 (128.7-799.5) | 314.2 (199.0-1028.2) | 0.217 | 0.806 |
| Blood uric acid (μmol/L) | 278.2±97.7 | 313.5±138.1 | 314.2±65.0 | 0.999 | 0.374 |
| Hcy (mmol/L) | 19.3±9.4 | 22.1±8.3* | 24.7±16.9**,# | 8.148 | 0.001 |
| TT3 (nmol/L) | 1.5±0.3 | 1.7±0.2 | 1.3±0.3 | 1.099 | 0.339 |
| TT4 (nmol/L) | 103.9±29.5 | 119.8±37.6 | 103.9±20.0 | 1.717 | 0.188 |
| TSH (mIu/L) | 2.0±1.6 | 2.9±1.8 | 2.6±2.3 | 0.949 | 0.393 |
Abbreviations: CRP, C-reactive protein; HBA1C, glycated hemoglobin; BNP, B-type natriuretic peptide; Hcy, homocysteine; TT3, Total Triiodothyronine; TT4, Thyroxine; TSH, Thyroid Stimulating Hormone.
Compared with mild frailty group;
*
P<0.05;
**
P<0.01.
Compared with moderate frailty group;
#
P<0.05;
##
P<0.01.