Table 3.

Meta-analysis of the TNF-α polymorphism and angina risk

Comparison	Population	N	Test of association			Mode	Test of heterogeneity
			OR	95% CI	P		χ2	P	I2
A versus. G	Overall	10	1.72	1.30-2.28	<0.001	Random	41.81	0	78.5
	Caucasian	6	1.14	0.92-1.41	0.243	Fixed	4.77	0.444	0
	Asian	4	2.44	2.06-2.88	<0.001	Fixed	4.12	0.249	27.2
	SA	5	1.49	0.96-2.31	0.076	Random	19.18	0.001	79.1
	UA	5	1.95	1.27-2.99	0.002	Random	19.81	0.001	79.8
AA versus. GG	Overall	10	3.35	2.51-4.48	<0.001	Fixed	10.12	0.334	11.8
	Caucasian	6	1.78	0.89-3.53	0.102	Fixed	2.91	0.713	0
	Asian	4	3.77	2.83-5.02	<0.001	Fixed	3.36	0.339	10.7
	SA	5	2.78	1.94-3.98	<0.001	Fixed	3.41	0.492	0
	UA	5	4.06	2.70-6.11	<0.001	Fixed	4.49	0.343	11.0
GA versus. GG	Overall	10	1.69	1.19-2.40	0.003	Random	35.86	0	74.9
	Caucasian	6	1.03	0.80-1.33	0.811	Fixed	2.98	0.704	0
	Asian	4	2.57	2.10-3.15	<0.001	Fixed	2.48	0.479	0
	SA	5	1.70	0.91-3.18	0.094	Random	23.70	0	83.1
	UA	5	1.66	1.06-2.61	0.027	Random	12.05	0.017	66.8
AA versus. GA/GG	Overall	10	2.40	1.91-3.03	<0.001	Fixed	8.32	0.503	0
	Caucasian	6	1.76	0.89-3.50	0.105	Fixed	2.61	0.760	0
	Asian	4	2.55	1.82-3.58	<0.001	Fixed	4.82	0.185	37.8
	SA	5	1.87	1.33-2.63	<0.001	Fixed	1.12	0.891	0
	UA	5	3.00	2.18-4.13	<0.001	Fixed	3.24	0.519	0
AA/GA versus. GG	Overall	10	1.84	1.27-2.65	0.001	Random	46.02	0	80.4
	Caucasian	6	1.09	0.85-1.39	0.494	Fixed	3.78	0.581	0
	Asian	4	2.92	2.43-3.50	<0.001	Fixed	2.10	0.551	0
	SA	5	1.70	0.91-3.16	0.096	Random	26.34	0	84.8
	UA	5	1.97	1.17-3.12	0.011	Random	19.28	0.001	79.3

SA, stable angina; UA, unstable angina; OR, odds ratio; CI, confidence interval; TNF-α, tumor necrosis factor-α.