Table 2.

Incidence and categorization of mutations detected in the BRCA1/2 genes among GC patients

Sr. no	Gene	NM:c.DNA	Protein	Nature (ClinVar)	Nature (In silico analysis)	No. patients
1	BRCA1	NM_007294.4:c.5467G>T	p.Ala1823Ser	Pathogenic	DC	7
2		NM_007294.4:c.5158A>G	p.Thr1720Ala	Benign	Non-DC	15
3		NM_007294.4:c.5117G>C	p.Gly1706Ala	Benign	Non-DC	9
4		NM_007294.4:c.5044G>A	p.Glu1682Lys	Benign	Non-DC	9
5		NM_007294.4:c.5024C>T	p.Thr1675Ile	Benign	Non-DC	11
6		NM_007294.4:c.4985T>C	p.Phe1662Ser	Benign	Non-DC	10
7		NM_007294.4:c.4956G>A	p.Met1652Ile	Benign	Non-DC	14
8		NM_007294.4:c.4955T>C	p.Met1652Thr	Benign	Non-DC	19
9		NM_007294.4:c.4913A>T	p.Glu1638Val	Benign	Non-DC	14
10		NM_007294.4:c.4910C>T	p.Pro1637Leu	Benign	Non-DC	11
11		NM_007294.4:c.4840C>T	p.Pro1614Ser	Benign	Non-DC	4
12		NM_007294.4:c.4837A>G	p.Ser1613Gly	Benign	Non-DC	12
13		NM_007294.4:c.4816A>G	p.Lys1606Glu	Benign	Non-DC	14
14		NM_007294.4:c.4729T>C	p.Ser1577Pro	Benign	Non-DC	12
15		NM_007294.4:c.4691T>C	p.Leu1564Pro	Benign	Non-DC	17
16		NM_007294.4:c.4682C>T	p.Thr1561Ile	Benign	Non-DC	5
1	BRCA2	NM_000059.4:c.275_276insCCAT	p.Gln92fs	Pathogenic	DC	7
2		NM_000059.4:c.1662T>G	p.Cys554Trp	Benign	Non-DC	18
3		NM_000059.4:c.1744A>C	p.Thr582Pro	Benign	Non-DC	21
4		NM_000059.4:c.1786G>C	p.Asp596His	Benign	Non-DC	12
5		NM_000059.4:c.1792A>G	p.Thr598Ala	Benign	Non-DC	13
6		NM_000059.4:c.1796C>T	p.Ser599Phe	Benign	Non-DC	11
7		NM_000059.4:c.1798T>C	p.Tyr600His	Benign	Non-DC	9
8		NM_000059.4:c.2350A>G	p.Met784Val	Benign	Non-DC	17

DC = Disease causing.