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. 2024 Oct 22;10(11):7155–7166. doi: 10.1021/acsbiomaterials.4c01226

Figure 4.

Figure 4

Transition of WM35 (RGP) and WM266-4 (skin metastasis) melanoma cells through constriction channels. The forced transition of the cells was mediated by an overall volumetric flow Q = 150 μL/min over the bifurcated microfluidic device. (A) Individual frame showing melanoma cells passing through the channel (red arrows indicate cells passing through the channel), which was quantified by transition time. (B) Dependence of the transition time on cell diameter. (C) Distributions of cell diameter and (D) transition time for control and colchicine-treated melanoma cells. Number of cells analyzed; WM35 control: n = 208 cells; WM35 + colchicine: n = 159 cells; WM266-4 control: n = 71 cells; and WM266-4 + colchicine: n = 147 cells.