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. 2024 Nov 12;22:298. doi: 10.1186/s12957-024-03581-5

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Differential dependencies of AML cells on mitochondrial/OXPHOS genes

A-G Dot plot depicting the gene dependency effect (CRISPR, DepMap Public 23Q4+ Score, Chronos) of AML cells on the indicated mitochondrial/OXPHOS genes (A: NADH : ubiquinone oxidoreductase subunit A6 (NDUFA6), B: NADH : ubiquinone oxidoreductase subunit C1 (NDUFC1), C: succinate dehydrogenase complex flavoprotein subunit A (SDHA), D: cytochrome B5 type A (CYB5A), E: solute carrier family 25 member 12 (SLC25A12), F: electron transfer flavoprotein subunit beta (ETFB) and G: carnitine palmitoyltransferase 1A (CPT1A)) plotted on the X-axis versus their corresponding mRNA expression level (log2(TPM+1) plotted on the Y-axis