Fig. 7.

Increased expression of glutathione peroxidase 4 (GPX4) is associated with higher percent of circulating and engrafted blasts as well as poor prognosis of AML patients and DNMT3a mutant AML cells are dependent on GPX4

A Kaplan–Meier survival curve depicting the hazard ratio (HR) and log-rank P values of the prognostic potential of GPX4 gene in AML patients based on Gene Expression Profiling Interactive Analysis (GEPIA) database. B, C The percent of circulating blasts (B) and blasts in the bone marrow (C) of GPX4^low and GPX4^high AML patients (BeatAML.2 dataset (38)). D Dot plot depicting the gene dependency effect (CRISPR, DepMap Public 23Q4 + Score, Chronos) of AML cells on GPX4 plotted on the X-axis versus their corresponding mRNA expression level (log2(TPM + 1) plotted on the Y-axis