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. 2024 Oct 24;62(11):e00786-24. doi: 10.1128/jcm.00786-24

Fig 3.

The table lists the biomarkers and includes study characteristics for HIV status, platform, and the risk of bias and applicability. Plots display sensitivity and specificity with confidence intervals.

Summary of adult PTB biomarkers and signatures meeting TPP criteria. Control groups: DM = diabetes mellitus, HC = healthy control, LTBI = latent TB infection, ORD = other respiratory disease, pre-ART = before initiation of anti-retroviral therapy. 2-marker signatures: HO-1, MMP-1; 3-marker signature: CALCOCO2, IFITM3, SAMD9L; 4-marker signature: CLEC3B, ECM1, IP-10, SELL; 6-marker signature: SYWC, kallistatin, C9, gelsolin, testican-2, aldolase C; 9-marker signature: fibrinogen, α-2-M, CRP, MMP-9, TTR, CFH, IFN-γ, IP-10, TNF. The reference standard results for risk of bias and applicability were low for all studies.