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. 2024 Nov 13;10(46):eadq8773. doi: 10.1126/sciadv.adq8773

Fig. 1. DNA origami nanostructures used to build NuPODs.

Fig. 1.

(A) A 60-nm-wide channel built by homodimerizing DNA nanopores with shape-complementary docking interfaces (blue and red). (B) A 79-nm-wide channel built by homodimerizing DNA nanopores with shape-complementary interfaces. (C) Small DNA basket with a docking interface (blue) compatible with the 60-nm channel. (D) Large DNA basket with a top docking interface (blue) compatible with the 79-nm channel and a bottom interface (red) compatible with the small basket. (E) A 60-nm channel capped by the small basket on one end. (F) A 79-nm channel capped by the two baskets on one end. For each panel, a cartoon model (DNA double helices are represented by rods) is shown next to representative TEM images. The experiment was repeated three times (technical replicates) with similar folding results. Scale bars, 100 nm.