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. 2024 Nov 13;10(46):eadr1017. doi: 10.1126/sciadv.adr1017

Fig. 2. R218Q pathogenic mutation alters the content of actin arrangement in podocytes.

Fig. 2.

Image shows an F-actin/G-actin assay. Control and PAN-stressed podocytes were examined for F-actin and G-actin content. Homozygous R218Q INF2 knock-in podocytes showed mild alteration in the basal condition in F-actin/G-actin distribution. In PAN-stressed conditions, both heterozygous and homozygous R218Q INF2 knock-in podocytes showed a prominent F-actin/G-actin distribution alteration. A representative immunoblot of three independent experiments was shown. The numerical value represents the mean F-actin/G-actin ratio for the PAN-stressed condition from three independent experiments. F/G, F-actin/G-actin.