Table 1.
Baseline demographic, clinical, procedural and imaging characteristics.
| Characteristics | Full cohort | Matched cohort | ||||||
|---|---|---|---|---|---|---|---|---|
| IVT + MT (n = 302) |
MT only (n = 308) |
P-Value | SMD | IVT + MT (n = 219) |
MT only (n = 219) |
P-Value | SD | |
| Female sex | 141 (46.7) | 159 (51.6) | 0.25 | 0.1 | 99 (45.2) | 114 (52.1) | 0.18 | 0.14 |
| Age, (median [IQR]) | 72 [61–81] | 73 [61–81] | 0.65 | 0.007 | 70 [61–80] | 73 [62–81] | 0.24 | 0.1 |
| Race | 0.008 | 0.23 | 0.15 | 0.25 | ||||
| White | 180 (77.9) | 179 (68.8) | 129 (75.4) | 126 (68.9) | ||||
| Black | 14 (6.1) | 35 (13.5) | 10 (5.8) | 21 (11.5) | ||||
| Hispanic | 1 (0.4) | 7 (2.7) | 1 (0.6) | 4 (2.2) | ||||
| Other | 36 (15.6) | 39 (15.0) | 35 (18.3) | 28 (16.0) | ||||
| Diabetes | 72 (24.0) | 93 (30.3) | 0.1 | 0.15 | 53 (24.3) | 63 (28.9) | 0.33 | 0.1 |
| Hypertension | 227 (75.4) | 215 (70.0) | 0.16 | 0.11 | 165 (75.7) | 149 (68.3) | 0.11 | 0.16 |
| Atrial fibrillation | 112 (37.3) | 109 (35.6) | 0.72 | 0.03 | 84 (38.5) | 85 (39.2) | 0.97 | 0.01 |
| Hyperlipidemia | 121 (40.3) | 123 (40.1) | >0.90 | 0.02 | 87 (39.9) | 83 (38.1) | 0.77 | 0.04 |
| Prior stroke | 30 (14.8) | 43 (16.7) | 0.67 | 0.05 | 22 (14.6) | 31 (17.6) | 0.55 | 0.08 |
| Premorbid mRS 0–1 | 173 (83.2) | 192 (77.4) | 0.16 | 0.18 | 188 (85.8) | 186 (84.9) | 0.89 | 0.03 |
| Admission NIHSS, (median [IQR]) | 16 [11–20] | 15 [10–20] | 0.43 | 0.06 | 16 [12–20] | 15 [11–20] | 0.46 | 0.06 |
| Imaging | 0.28 | 0.34 | 0.1 | 0.52 | ||||
| CTA | 24 (40.7) | 61 (53.0) | 21 (44.7) | 51 (63.0) | ||||
| CTA + CTP | 1 (1.7) | 2 (1.7) | 0 (0.0) | 2 (2.5) | ||||
| CTP | 29 (49.2) | 46 (40.0) | 21 (44.7) | 23 (28.4) | ||||
| DWI | 2 (3.4) | 5 (4.3) | 2 (4.3) | 4 (4.9) | ||||
| Others | 3 (5.1) | 1 (0.9) | 3 (6.4) | 1 (1.2) | ||||
| ASPECTS 0–5 | 32 (10.6) | 46 (14.9) | 0.14 | 0.13 | 29 (12.7) | 21 (9.2) | 0.29 | 0.11 |
| Occluded vessel location | 0.69 | 0.16 | 0.54 | 0.2 | ||||
| ICA | 70 (23.2) | 65 (21.1) | 47 (21.5) | 50 (22.8) | ||||
| ICA + M1 | 24 (7.9) | 28 (9.1) | 19 (8.7) | 16 (7.3) | ||||
| ICA + M1 + M2 | 4 (1.3) | 3 (1.0) | 2 (0.9) | 3 (1.4) | ||||
| ICA + M2 | 4 (1.3) | 5 (1.6) | 3 (1.4) | 1 (0.5) | ||||
| M1 | 142 (47.0) | 130 (42.2) | 108 (49.3) | 94 (42.9) | ||||
| M1 + M2 | 11 (3.6) | 15 (4.9) | 10 (4.6) | 12 (5.5) | ||||
| M2 | 47 (15.6) | 62 (20.1) | 30 (13.7) | 43 (19.6) | ||||
| Time from symptoms onset to arterial puncture, minutes, (median [IQR]) | 230 [150–308] | 357 [186–808] | <0.001 | 0.5 | 242 [150–341] | 237 [160–405] | 0.45 | 0.09 |
| Technique | 0.29 | 0.20 | 0.56 | 0.15 | ||||
| Contact aspiration | 98 (40.3) | 132 (48.2) | 77 (42.3) | 85 (45.2) | ||||
| Stent retriever | 47 (19.3) | 45 (16.4) | 32 (17.6) | 37 (19.7) | ||||
| Combined | 89 (36.6) | 82 (29.9) | 67 (36.8) | 57 (30.3) | ||||
| Others | 9 (3.8) | 15 (5.5) | 6 (3.3) | 9 (4.8) | ||||
| Balloon guide catheter | 28 (11.0) | 41 (15.0) | 0.22 | 0.12 | 22 (11.6) | 26 (13.8) | 0.63 | 0.07 |
| Angioplasty | 9 (4.5) | 23 (11.1) | 0.40 | 0.10 | 7 (5.6) | 20 (10.4) | 0.16 | 0.02 |
| Intracranial stent placed | 9 (4.4) | 14 (6.7) | 0.91 | 0.09 | 9 (4.5) | 11 (5.02) | 1.00 | 0.07 |
| Procedure duration, minutes (median [IQR]) | 62 [41–97] | 65 [41–92] | 0.93 | 0.07 | 64 [41–95] | 70 [45–95] | 0.47 | 0.06 |
| Final mTICI | 0.447 | 0.103 | 0.16 | 0.19 | ||||
| 0 | 116 (37.7) | 120 (39.7) | 92 (42.0) | 76 (34.7) | ||||
| 1 | 36 (11.7) | 43 (14.2) | 33 (15.1) | 29 (13.2) | ||||
| 2A | 156 (50.6) | 139 (46.0) | 94 (42.9) | 114 (52.1) | ||||
MT, mechanical thrombectomy; IVT, intravenous thrombolysis; ICA, internal carotid artery; M1/M2, M1/M2 segment of the middle cerebral artery; NIHSS, National Institutes of Health Stroke Scale; ASPECTS, Alberta Stroke Program Early CT Score; mTICI, modified thrombolysis in cerebral infarction; IQR, interquartile range; SD, standard deviation.
Data were expressed as number of cases (%), unless otherwise indicated.