Figure 1.

Association of 45 replicated circulating proteins with incident myocardial infarction in SIMPLER cohorts (n = 11 751). Hazard ratios (HR) with 95% confidence intervals (CI) are expressed per standard deviation unit change in protein measurements. Proteins were identified and passed FDR adjustment in the discovery sample, were validated in a replication sample (P < 0.05), and had P < 0.05 in the multivariable analysis. The models were adjusted for age (as the time scale), sex, education attainment, project, baseline cigarette smoking, alcohol consumption, walking/bicycling, exercise, adherence to the mDASH diet, body mass index, systolic blood pressure, and blood levels of fasting glucose, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. * Protein METRNL was not available in the UK Biobank data and, therefore, was not replicated