FIGURE 1.

Neoadjuvant combined systemic therapy and radioembolization (SYS-TARE) protocol for unresectable intrahepatic. iCC, intrahepatic cholangiocarcinoma; GemCis, gemcitabine + cisplatin; SD, stable disease; PR, partial response; CR, complete response; PD, progressive disease; MDT, multidisciplinary team; WL, waitlist; CT, chemotherapy. Second-line chemotherapy was indicated according to standard of care, preferably with targeted therapy if actionable mutations were present at next-generation sequencing analysis. Maintenance chemotherapy included additional cycles of GemCis until transplant or disease progression.