TABLE 2.
Characteristics of transplanted patients at listing, transplant, and follow-up.
| Overall (n = 4) | Case 1 | Case 2 | Case 3 | Case 4 | |
|---|---|---|---|---|---|
| Interval between diagnosis and LT listing (months) | Median 6 | 5 | 5 | 17 | 7 |
| MELD-NA at listing | Median 7 | 7 | 6 | 8 | 7 |
| Presence of viable tumor at listing (DWI or PET) | — | Yes | — | Yes | |
| RECIST response at listing | 100% SD | SD | SD | SD | SD |
| Choi response at listing Decrease in tumor density from baseline to listing |
100% PR Median 52.5% |
PR 47% |
PR 35% |
PR 58% |
PR 73% |
| CEA at listing CA19-9 at listing |
Median 3.9 Median 40 |
4.05 22 |
3.2 38.4 |
6.63 46.9 |
3.8 42 |
| Time on waitlist (days) | Median 57 | 49 | 2 | 65 | 127 |
| Interval diagnosis and LT (months) | Median 10.5 | 10 | 5.5 | 19 | 11 |
| Interval last treatment and LT (days) | Median 36 | 59 | 58 | 5 | 14 |
| CEA at LT (mg/dL) CA19-9 at LT (mg/dL) |
Median 3.3 Median 43 |
3.35 17.7 |
2.7 41.5 |
8.5 75.7 |
3.4 44.5 |
| MELD-Na at LT | Median 7 | 6 | 7 | 7 | 7 |
| LT duration (hours) | Median 10 | 13 | 11 | 9 | 9 |
| Venovenous bypass | 2/4 (50%) | Yes | No | Yes | No |
| Final pathology | 4/4 iCC | iCC | iCC | iCC | iCC |
| TNM staging T1aN0 T2N0 |
2/4 (50%) 2/4 (50%) |
ypT2N0 | ypT1aN0 | ypT1aN0 | ypT2N0 |
| Number of lesions | Median 1 | 1 | 1 | 2 | 1 |
| Size of lesions (mm) | Median 74 | 72 | 23 | 76 | 84 |
| % viable tumor at final pathology | Median 25% | 30% | 30% | <5% | 20% |
| Grading | 3/4 (75%) G3 1/4 (25%) G2 |
G3 | G3 | G3 | G2 |
| Lymphovascular invasion | 2/4 (50%) | Present | Absent | Absent | Present |
| Perineural invasion | 2/4 (50%) | Present | Absent | Absent | Present |
| Number of metastatic/retrieved lymph nodes | 0/8 | 0/7 | 0/9 | 0/10 | 0/6 |
| LOS (days) | Median 11.5 | 12 | 11 | 44 | 10 |
| Postoperative complications | Major complications 2/4 (50%) | Pleural effusion CD II |
Yes, partial hepatic artery thrombosis CD IIIa CCI 45.4 |
Yes Biliary stenosis, hemoperitoneum, duodenal fistula CD IIIb CCI 73.7 |
No |
| Follow-up (months) | Median 26 | 73 | 40 | 12 | 8 |
| Recurrence | 0/4 | No | No | No | No |
| Alive, NED at latest follow up | 4/4 | Yes | Yes | Yes | Yes |
Data is number (percentage) and median (interquartile range). LT, liver transplant; CRLM, colorectal liver metastases; T-bil, total bilirubin; MELD-Na, model for end stage liver disease–sodium; DBD, donation after brain death; LDLT, living donor liver transplant; CIT, cold ischemia time; WIT, warm ischemia time; LOS, length of stay; CD, clavien dindo grade; CCI: comprehensive complication index; NED, no evidence of disease.