Figure 3: Associations between air toxic levels and CpG methylation.

(A) The circos plot shows the 81 associations between air toxic and CpG methylation levels that were significant at P < 9e-8. The green section represents air toxics (ordered alphabetically) and the black/gray section represents CpGs by chromosome location. Edges indicate significant associations, with positive effects shown in red and negative effects shown in blue. The top three positive effects and top four negative effects are shown with thicker edges weighted by absolute t-statistic and labelled in black. Additionally, the association between phosphine and a CpG associated with THBS1, which factors prominently in downstream results, is also shown and labelled in maroon. (B) The boxplots show the covariate-adjusted methylation values for each air toxic by quartile for the eight associations shown in (A). Blue boxes are for negatively associated air toxics and red boxes indicate positively associated air toxics.