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A. Western blotting was performed to detect changes in p-PI3K/PI3K and p-AKT/AKT ratios in CFPAC-1 and PANC-1 cell knockdown models; B. Western blotting was performed to detect changes in p-PI3K/PI3K and p-AKT/AKT ratios in the Mia-PaCa cell overexpression model; C. IC50 values of MK2206 and GSK2110183 in Mia-PaCa cells determined by CCK8 assay; D. Drug survival assay.
