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. 2024 Oct 15;14(10):4717–4730. doi: 10.62347/YQWJ7498

Figure 6.

Figure 6

Regulation of EMT by administration of Ras/p53/JAK/PI3K signaling inhibitors. The administration of Ras inhibitor (salirasib), JAK inhibitor (Bacrivitinib), and PI3K inhibitor (Buparlisib) upregulated E-cadherin expression and downregulated α-SMA, Snail, and Slug expression in prostate cancer cells transfected with pCMV-EPS8 when compared with prostate cancer cells treated with pCMV-GFP. A. Western blotting images of EMT markers in the LNCaP cells. B. Quantification of EMT markers expression in LNCaP cells. C. Western blotting images of EMT markers in the LNCaP Enz-R cells. D. Quantification of EMT markers expression in LNCaP Enz-R cells. The triplicates of western blotting images are shown in Figures S6 and S7. *P < 0.05 vs. Control and #P < 0.05 vs. pCMV-GFP. α-SMA, α-smooth muscle actin; EMT, epithelial-to-mesenchymal transition; Enz-R, enzalutamide-resistant; GFP, green fluorescent protein.