Extended Data Fig. 8. Dual anti-PD-1/anti-CTLA4 blockade reshapes the immune contexture of Stk11- and/or Keap1-deficient models of KRAS-mutant NSCLC.
a. FACS-based assessment of single and dual ICB-induced changes in the abundance of distinct T cell (left panels) and myeloid cell (right panels) subsets in the microenvironment of Stk11-deficient (KL5) and Keap1-deficient (KK) models. Error bars indicate standard deviation from the mean (N = 7-8 mice/group). The Mann–Whitney U test was used for pairwise comparisons of the abundance of immune cell subsets. Statistical significance is indicated at the P ≤ 0.05 (*), P ≤ 0.01 (**), and P ≤ 0.001 (***) levels. b. ICB-induced changes in the abundance of distinct T cell and dendritic cell subsets in the microenvironment of KLK, KK and KL5 models assessed by FACS. Error bars indicate standard deviation from the mean (N = 7-8 mice/group). c. FACS-based quantification of lymphoid and myeloid cell subsets in KL2 allograft tumours in response to single or dual ICB. Error bars indicate standard deviation from the mean (N = 7-8 mice/group). The Mann–Whitney U test was used for comparison of the abundance of immune cell subsets. Statistical significance in all panels is indicated at the P ≤ 0.05 (*), P ≤ 0.01 (**), and P ≤ 0.001 (***) levels.