Extended Data Fig. 9. Treatment-induced immune modulation in the TIME of Stk11- and/or Keap1-deficient models of KRAS-mutant NSCLC.

a,b, FACS-based enumeration of lymphoid (a) and myeloid cell (b) subsets in isogenic K (LKR13 Kras^G12D-mutant; Stk11/Keap1 WT) and KLK (Kras^G12D-mutant, Stk11/Keap1 knockout, clone 17) allograft models as well as in the KL5 (Kras^G12C-mutant Stk11-deficient) allograft model (N = 3-5 mice/group for the K and KLK models and N = 6-7 mice/group for the KL5 model). The Mann–Whitney U test was used for pairwise statistical comparisons. Error bars represent standard deviation from the mean. Statistical significance is indicated at the P ≤ 0.05 (*), P ≤ 0.01 (**), and P ≤ 0.001 (***) levels.

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