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. 2024 Oct 9;635(8038):462–471. doi: 10.1038/s41586-024-07943-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Extended Data Fig. 4 — a. Kaplan–Meier estimates of PFS according to BICR per RECIST v1.1 with TDCT (light blue curve) vs DCT (dark blue curve) vs CT (red curve) in patients bearing KRAS^MUT (left panel) and KRAS^WT (right panel) metastatic nsNSCLC. Landmark 12-month PFS rates in each of the treatment arms are also shown (dotted lines). b,c. Kaplan–Meier estimates of PFS according to BICR per RECIST v1.1 (b) and OS (c) with TDCT vs DCT vs CT in patients bearing KRAS^MUT; STK11^MUT and/or KEAP1^MUT (left panel) and KRAS^MUT; STK11^WT and KEAP1^WT (right panel) metastatic nsNSCLC. PFS and ORR analyses were based on a data cut-off date of July 24, 2019. OS analyses were based on a data cut-off date of March 12, 2021. HRs and 95% CIs were estimated using unstratified Cox proportional hazards models.