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. 2024 Nov 13;15:9839. doi: 10.1038/s41467-024-53595-6

Fig. 3. Performance of MG polygenic risk scores.

Fig. 3

Results of polygenic risk scoring of the combined target sample of CCM and LUMC cases and controls across all 10 PTs. Panel a shows the proportion of variance explained through the logistic regression models for PTs 1-10. Panel b shows the density distribution of the z-transformed best-performing PT (P < 0.001) for cases (orange) and controls (blue). Panel c shows the odds ratios (OR) from logistic regression models for PT P < 0.001 across ten deciles of the PRS along with the corresponding 95% confidence intervals (error bars). The target sample was scored using the combined MG leave-one-out training dataset of 5318 cases and 431,304 controls.PRS polygenic risk score.