Table 2.
Discovery GWAS, replication, and combined meta-analysis results for EOMG
| Nearest gene | Index SNP | CHR | BP (GRCh37) | A1/A2 | FRQ case | FRQ control | Proxy | P | OR | SE | P-rep | OR-rep | SE-rep | P-comb | OR-comb | SE-comb |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PTPN22 | rs2476601a | 1 | 114377568 | A/G | 0.156 | 0.136 | same | 3.61e−06 | 1.46976 | 0.0653 | 2.77e−04 | 1.30479 | 0.074616 | 1.15e−11 | 1.39585 | 0.0491 |
| MHC | rs2853986a | 6 | 31338844 | T/C | 0.682 | 0.907 | same | 4.06e−105 | 0.2395 | 0.0656 | 1.28e−11 | 0.636760 | 0.064406 | 2.67e−91 | 0.39404 | 0.046 |
The table presents the results from the discovery-, replication-, and combined inverse-variance-weighted fixed-effects meta-analyses.
BP (GRCh37) Base Pair position on Genome Reference Consortium Human Build 37, CHR chromosome, comb combined meta-analysis of discovery and control GWAS results, FRQ frequency.
aPreviously published as genome-wide significant locus.