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. 2024 Nov 13;14:27782. doi: 10.1038/s41598-024-79694-4

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/.

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Fig. 3 — Barbed sidehole catheter. The barbs retain the catheter in the tumor, and the sideholes allow intratumoral drug infusion. A. Colorized SEM image of a honey bee stinger, showing the barbs that retain the stinger at the venom injection site (Image credit: Power & Syred / Science Photo Library). B. Backlit photograph of the translucent barbed sidehole catheter. Scale bar: 2 mm. C. Methylene blue was injected into the catheter, to show the main catheter channel, as well as the sidehole channels. D. Fluid jets emerging from the barbed sidehole catheter.