Table 5.
Univariable and multivariable Cox analysis of overall survival in patients with DST-1st.
| Variables | Univariable analysis | Multivariable analysis | |
|---|---|---|---|
| HR (95% CI) P-value | HR (95% CI) P-value | ||
| Sex | |||
| Male | Reference | Reference | |
| Female | 0.732 (0.684-0783) < 0.001 | 0.838 (0.780–0.899) < 0.001 | |
| Age | 1.033 (1.029–1.036) < 0.001 | 1.035 (1.032–1.038) < 0.001 | |
| Race | |||
| White | Reference | Reference | |
| Black | 1.302 (1.163–1.456) < 0.001 | 1.224 (1.092–1.373) < 0.001 | |
| Other | 0.975 (0.870–1.091) 0.655 | 0.808 (0.719–0.907) < 0.001 | |
| Grade | |||
| Grade I | Reference | Reference | |
| Grade II | 1.289 (1.138–1.460) < 0.001 | 1.211 (1.061–1.381) 0.004 | |
| Grade III | 2.566 (2.246–2.932) < 0.001 | 1.769 (1.537–2.037) < 0.001 | |
| Grade IV | 3.022 (2.338–3.907) < 0.001 | 2.105 (1.623–2.730) < 0.001 | |
| Unknown | 1.259 (1.092–1.453) 0.002 | 1.018 (0.877–1.183) 0.811 | |
| Summary stage | |||
| Localized | Reference | Reference | |
| Regional | 1.743 (1.612–1.884) < 0.001 | 1.836 (1.690–1.995) < 0.001 | |
| Distant | 6.880 (6.262–7.560) < 0.001 | 7.321 (6.612–8.108) < 0.001 | |
| Unknown | 2.170 (1.549–2.868) < 0.001 | 1.991 (1.442–2.751) < 0.001 | |
| Histology | |||
| Adenocarcinoma | Reference | Reference | |
| Other | 1.163 (1.070–1.263) < 0.001 | 0.823 (0.723–0.938) 0.004 | |
| Surgery | |||
| Yes | Reference | Reference | |
| No | 4.186 (3.766–4.653) < 0.001 | 2.564 (2.259–2.911) < 0.001 | |
| Radiation | |||
| Yes | Reference | Reference | |
| None/Unknown | 0.686 (0.634–0.742) < 0.001 | 0.146 | |
| Chemotherapy | |||
| Yes | Reference | Reference | |
| None/Unknown | 0.578 (0.540–0.619) < 0.001 | 0.369 | |
| Marital status | |||
| Married | Reference | Reference | |
| Not married | 1.287 (1.201–1.397) < 0.001 | 1.384 (1.288–1.486) < 0.001 | |
| Prior thyroid cancer history | |||
| With | 0.583 (0.510–0.666) < 0.001 | 0.485 (0.425–0.555) < 0.001 | |
| Without | Reference | Reference | |
| The primary site | |||
| Esophagus | Reference | Reference | |
| Stomach | 0.504 (0.414–0.613) < 0.001 | 0.977 (0.800-1.193) 0.819 | |
| Small intestine | 0.181 (0.141–0.232) < 0.001 | 0.441 (0.338–0.575) < 0.001 | |
| Colon | 0.231 (0.194–0.275) < 0.001 | 0.462 (0.382–0.559) < 0.001 | |
| Rectum | 0.233 (0.577–0.868) < 0.001 | 0.505 (0.416–0.612) < 0.001 | |
| Liver | 0.708 (0.111–0.345) < 0.001 | 1.993 (1.587–2.503) < 0.001 | |
| Pancreas | 0.936 (0.672–1.302) 0.693 | 1.684 (1.204–2.356) 0.002 | |