Table 6.

Multivariable competing risk regression analysis of DST-specific survival in the two groups of patients.

Variables	Multivariable analysis (TC-1st)		Multivariable analysis (DST-1st)
	HR (95% CI) P-value		HR (95% CI) P-value
Sex
Male	Reference		Reference
Female	0.91 (0.83-1.00) 0.046		0.97 (0.87–1.08) 0.60
Age	1.01 (1.00-1.01) < 0.001		1.01 (1.01–1.02) < 0.001
Race
White	Reference		Reference
Black	1.18 (1.03–1.35) 0.016		1.19 (1.00-1.43) 0.054
Other	1.11 (0.97–1.27) 0.130		0.95(0.80–1.13) 0.56
Grade
Grade I	Reference		Reference
Grade II	1.68 (1.35–2.09) < 0.001		1.28 (1.05–1.58) 0.017
Grade III	2.21 (1.76–2.78) < 0.001		2.07 (1.66–2.57) < 0.001
Grade IV	1.91 (1.27–2.87) 0.002		1.42 (0.87–2.31) 0.16
Unknown	1.52 (1.22–1.90) < 0.001		1.11 (0.87–1.41) 0.40
Summary stage
Localized	Reference		Reference
Regional	2.45 (2.18–2.76) < 0.001		2.45 (2.10–2.87) < 0.001
Distant	5.10 (4.41–5.89) < 0.001		8.77 (7.29–10.6) < 0.001
Unknown	2.18 (1.70–2.80) < 0.001		3.96 (2.49–6.31) < 0.001
Histology
Adenocarcinoma	Reference		Reference
Other	0.90 (0.78–1.04) 0.140		1.24(1.02–1.51) 0.031
Surgery
Yes	Reference		Reference
No	2.15 (1.90–2.43) < 0.001		1.76 (1.43–2.17) < 0.001
Radiation
Yes	Reference		Reference
None/Unknown	0.91 (0.80–1.05) 0.190		0.76 (0.64–0.90) 0.002
Chemotherapy
Yes	Reference		Reference
None/Unknown	0.88 (0.79–0.97) 0.013		0.71 (0.62–0.83) < 0.001
Marital status
Married	Reference		Reference
Not married	1.04 (0.95–1.14) 0.360		1.05 (0.94–1.17) 0.39
Prior thyroid cancer history
With	0.69 (0.59–0.81) < 0.001		0.51 (0.42–0.62) < 0.001
Without	Reference		Reference
The primary site
Esophagus	Reference		Reference
Stomach	0.67 (0.54–0.82) < 0.001		0.78 (0.58–1.05) 0.10
Small intestine	0.24 (0.17–0.35) < 0.001		0.15 (0.09–0.25) < 0.001
Colon	0.53 (0.42–0.66) < 0.001		0.60 (0.45–0.82) 0.001
Rectum	0.23 (0.18–0.28) < 0.001		0.28 (0.21–0.37) < 0.001
Liver	1.36 (1.08–1.72) 0.010		1.73 (1.18–2.52) 0.005
Pancreas	1.40 (1.06–1.84) 0.017		1.68 (0.98–2.88) 0.058