Table 4.
Mean ADN values of labeled cells (MDLC) and of unlabeled cells (MDUC) and percent of dead cells calculated for different amounts of activity of 177Lu- and 161Tb-DOTATOC within clusters of 100, 500 and 1000 µm considering 10, 40 or 70% of labeled cells
| Cluster Activity (Bq) | Labeled cells (%) | Activity/labeled cell (Bq/cell) | no disintegrations/cell (labeled cell) | MDLC (Gy) | MDUC (Gy) | SF (%) | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| 177Lu-RP | 161 Tb-RP | 177Lu-RP | 161 Tb-RP | 177Lu-RP | 161 Tb-RP | 177Lu-RP | 161 Tb-RP | |||
| Cluster Size 100 μm radius (1021 cells) | ||||||||||
| 1.15 | 10 | 1.13E−02 | 9416 | 9701 | 2.89 | 8.06 | 1.04 | 1.63 | 74.913 | 61.305 |
| 40 | 2.82E−03 | 2354 | 2425 | 1.49 | 3.29 | 1.02 | 1.64 | 76.204 | 55.429 | |
| 70 | 1.61E−03 | 1343 | 1384 | 1.29 | 2.56 | 1.03 | 1.63 | 77.669 | 60.416 | |
| 5.98 | 10 | 5.86E−02 | 48,966 | 50,443 | 15.00 | 43.50 | 5.42 | 8.81 | 21.880 | 8.812 |
| 40 | 1.47E−02 | 12,241 | 12,611 | 7.76 | 17.80 | 5.33 | 8.87 | 19.304 | 5.093 | |
| 70 | 8.37E−03 | 6985 | 7196 | 6.71 | 13.80 | 5.37 | 8.80 | 18.968 | 3.812 | |
| 11.99 | 10 | 1.18E−01 | 98,177 | 101,139 | 30.00 | 87.00 | 10.80 | 17.60 | 3.132 | 1.179 |
| 40 | 2.94E−02 | 24,544 | 25,285 | 15.50 | 35.50 | 10.70 | 17.70 | 2.253 | 0.294 | |
| 70 | 1.68E−02 | 14,006 | 14,428 | 13.40 | 27.60 | 10.70 | 17.60 | 1.958 | 0.195 | |
| 23.11 | 10 | 2.26E−01 | 189,230 | 194,940 | 57.70 | 161.00 | 20.90 | 32.60 | 0.196 | 0.098 |
| 40 | 5.66E−02 | 47,308 | 48,735 | 29.90 | 65.80 | 20.50 | 32.80 | 0.000 | 0.000 | |
| 70 | 3.23E−02 | 26,995 | 27,810 | 25.80 | 51.10 | 20.70 | 32.60 | 0.000 | 0.000 | |
| Cluster Size 500 μm radius (127,675 cells) | ||||||||||
| 144 | 10 | 1.13E−02 | 9416 | 9691 | 4.96 | 10.50 | 3.13 | 3.89 | 42.640 | 32.220 |
| 40 | 2.82E−03 | 2354 | 2423 | 3.60 | 5.54 | 3.13 | 3.89 | 42.180 | 30.260 | |
| 70 | 1.61E−03 | 1343 | 1384 | 3.40 | 4.83 | 3.13 | 3.89 | 42.310 | 29.740 | |
| 748 | 10 | 5.86E−02 | 48,966 | 50,396 | 25.80 | 56.50 | 16.30 | 21.00 | 0.429 | 0.136 |
| 40 | 1.46E−02 | 12,241 | 12,598 | 18.70 | 29.90 | 16.30 | 21.00 | 0.326 | 0.038 | |
| 70 | 8.37E−03 | 6985 | 7199 | 17.70 | 29.00 | 16.30 | 23.30 | 0.295 | 0.010 | |
| 1499 | 10 | 1.17E−01 | 98,177 | 101,044 | 51.60 | 113.00 | 32.60 | 42.10 | 0.000 | 0.001 |
| 40 | 2.94E−02 | 24,544 | 25,260 | 37.40 | 59.80 | 32.60 | 42.00 | 0.000 | 0.000 | |
| 70 | 1.68E−02 | 14,006 | 14,434 | 35.30 | 52.20 | 32.60 | 42.00 | 0.000 | 0.000 | |
| 2890 | 10 | 2.26E−01 | 189,230 | 194,756 | 99.30 | 209.00 | 62.60 | 77.90 | 0.000 | 0.000 |
| 40 | 5.66E−02 | 47,308 | 48,687 | 72.00 | 111.00 | 62.70 | 77.80 | 0.000 | 0.000 | |
| 70 | 3.23E−02 | 26,995 | 27,821 | 67.90 | 96.60 | 62.70 | 77.80 | 0.000 | 0.000 | |
| Cluster Size 1000 μm radius (1,023,349 cells) | ||||||||||
| 1153 | 10 | 1.13E−02 | 9416 | 9691 | 5.97 | 11.60 | 4.13 | 5.03 | 31.380 | 22.464 |
| 40 | 2.82E−03 | 2354 | 2423 | 4.59 | 6.68 | 4.13 | 5.03 | 31.080 | 20.900 | |
| 70 | 1.61E−03 | 1343 | 1384 | 4.39 | 5.97 | 4.13 | 5.03 | 31.070 | 20.640 | |
| 5994 | 10 | 5.86E−02 | 48,966 | 50,394 | 31.00 | 62.70 | 21.50 | 27.10 | 0.060 | 0.011 |
| 40 | 1.46E−02 | 12,241 | 12,598 | 23.80 | 36.00 | 21.50 | 27.20 | 0.044 | 0.003 | |
| 70 | 8.37E−03 | 6985 | 7199 | 22.80 | 32.20 | 21.50 | 27.20 | 0.041 | 0.002 | |
| 12,018 | 10 | 1.17E−01 | 98,177 | 101,040 | 62.10 | 125.00 | 42.90 | 54.30 | 0.000 | 0.000 |
| 40 | 2.94E−02 | 24,544 | 25,260 | 47.70 | 72.10 | 42.90 | 54.30 | 0.000 | 0.000 | |
| 70 | 1.68E−02 | 14,006 | 14,434 | 45.70 | 64.50 | 42.90 | 54.30 | 0.000 | 0.000 | |
| 23,163 | 10 | 2.26E−01 | 189,230 | 194,749 | 119.00 | 232.00 | 82.60 | 101.00 | 0.000 | 0.000 |
| 40 | 5.66E−02 | 47,308 | 48,687 | 91.70 | 134.00 | 82.50 | 101.00 | 0.000 | 0.000 | |
| 70 | 3.23E−02 | 26,995 | 27,821 | 87.80 | 119.00 | 82.50 | 101.00 | 0.000 | 0.000 | |