Fig. 9.

Schematic Diagram of VPSPr-Associated PK-resistant PrPSc Fragments, Adapted from Zhang et al²¹. The gray bar at the top represents full length human PrP (23–231). The purple bars represent fragments bound to N-terminal antibody 1E4 (96–105), the green bars represent fragments bound to C-terminal antibody EP1802Y (217–226), and the red fragment represents the fragment exclusively bound to N-terminal antibody 12B2 (89–93). VPSPr fragments with known cleavage sites are labelled with an amino acid cleavage site number²¹, whereas dotted lines represent the regions of currently unknown cleavage sites.