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. 2024 Nov 13;13(1):39. doi: 10.1038/s41389-024-00540-3

Fig. 1. Intratumoral glycine levels and ser/gly pathway PSPH genetic alterations in the pathogenesis of GBM.

Fig. 1

A Kaplan-Meier curves illustrating differences in survival in 216 glioma patients divided into three groups based on quantiles of intratumoral glycine levels irrespective of glioma subtype. B The main PSPH mutation observed in GBM patients is the recurrent PSPH V116I mutation (cBioPortal, TCGA, Firehose Legacy). C The PSPH V116I mutation is located at the inner core of the PSPH hydrolase domain. D PSPH gene expression analysis from GEPIA data platform comparing GBM tumor samples with normal tissue controls. Statistical significance p < 0.05 (*).