| Methods |
Quasi‐randomised, unblinded trial. 99 patients, 31 HBOT, 29 control. |
| Participants |
Patients with a history of closed head injury and who are comatose with 'acute midbrain syndrome'. |
| Interventions |
HBOT at 1.5 ATA daily ‐ time of each sessions and total number of sessions unknown. Standard care given to both groups described as 'usual intensive care regimen'. |
| Outcomes |
Complete recovery, mortality. |
| Notes |
|
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Random sequence generation (selection bias) |
High risk |
Appears to have been a sequential allocation: "every second patient received hyperbaric oxygenation" . |
| Allocation concealment (selection bias) |
High risk |
No evidence of concealment and it seems unlikely: "every second patient received hyperbaric oxygenation". |
| Blinding (performance bias and detection bias)
All outcomes |
High risk |
No evidence of blinding and appears unlikely. |
| Incomplete outcome data (attrition bias)
All outcomes |
Low risk |
No losses to follow‐up. |
| Selective reporting (reporting bias) |
Low risk |
All outcomes reported. |
| Other bias |
Low risk |
No other obvious potential for bias. |
