Rockswold 2010.

Methods	Randomised, unblinded trial to test the feasibility of proposed larger RCT to come.
Participants	Adult patients with acute traumatic brain injury (within 24 hrs) and GCS <9 admitted to a neurosurgical intensive care setting.
Interventions	Two control groups: Intensive neurosurgical care according to current guidelines of Brain Trauma Foundation and 100% oxygen at 1 ATA for 3 hours daily (normobaric arm in this study) and intensive neurosurgical care without extra oxygen (standard care arm). Experimental group: As above plus 100% oxygen at 1.5 ATA for one hour daily for three days.
Outcomes	Multiple measures of brain metabolism, including oxygenation, oxygen consumption, lactate etc. Also intracranial pressure (relevant for this review).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomized, but no description of details: "Twenty‐six patients were randomised to the HBO2 group..."
Allocation concealment (selection bias)	Low risk	Probably concealment at entry: "After study eligibility and a GCS score were established, informed consent was obtained from each participant. Randomiszation occurred immediately after consenting..."
Blinding (performance bias and detection bias) All outcomes	High risk	No attempt at blinding.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients entered are accounted for with only minor data loss.
Selective reporting (reporting bias)	Low risk	All outcomes were reported by intention to treat.
Other bias	Low risk	No clear other bias.